| 甲基异柳磷毒性研究 |
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| 引用本文： | 邬惠琼,赖志伟,徐汉宫,宋瑞琨,马谭庚,石年,刘瑞明,刘毓谷.甲基异柳磷毒性研究[J].华中科技大学学报(医学版),1986(5). |
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| 作者姓名： | 邬惠琼 赖志伟 徐汉宫 宋瑞琨 马谭庚 石年 刘瑞明 刘毓谷 |
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| 作者单位： | 同济医科大学卫生系环境毒理研究室
(邬惠琼，赖志伟，徐汉宫，宋瑞琨，马谭庚，石年，刘瑞明)，同济医科大学卫生系环境毒理研究室(刘毓谷) |
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| 摘 要： | 甲基异柳磷是我国新发展的一种以防治地下害虫为主、兼治地面害虫的新型有机磷农药。本研究包括一系列毒性试验;并从亚细胞水平上对该农药中毒机理进行了探讨。研究结果表明甲基异柳磷杀虫效果显著,在体内代谢迅速,无明显蓄积毒性,未发现致畸性、致突变性、生殖毒性及迟发神经毒性,对人、畜比较安全。目前,已列入国家作为取代六六六的重点推广品种。
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| 关 键 词： | 甲基异柳磷 农药毒性 迟发神经毒性 毒物代谢动力学 微粒体酶 线粒体 |
Toxicological Studies on The Organophosphorus Insecticide Methyl-ISP |
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| Wu Huiqiong,Lai Zhiwei,Xu Hangong,Song RuikunMa Tangeng,Shi Nian,Liu Ruiming,Liu YuguResearch Laboratory of Environmental Toxicology,Tongji Medical University.Toxicological Studies on The Organophosphorus Insecticide Methyl-ISP[J].Journal of Huazhong University of Science and Technology(Health Sciences),1986(5). |
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| Authors: | Wu Huiqiong Lai Zhiwei Xu Hangong Song RuikunMa Tangeng Shi Nian Liu Ruiming Liu YuguResearch Laboratory of Environmental Toxicology Tongji Medical University |
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| Abstract: | A series of lexicological tests of Methyl-ISP were performed.The results showed that Methyl-ISP is metabolized quickly in the body and has only a very low toxicity.No obvious accumulation,chronic toxicity,teragenicity,mutation,reproductive toxicity and delayed neurotoxicity were observed.A preliminary study was made to elucidate the possible mechanism of intoxication on.subcel-lular level. |
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| Keywords: | Methy-ISP toxicity of insecticide delayed neurotoxicity toxicokinetics microsomal enzymes mitochondria |
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