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| 恶性淋巴瘤患者脑脊液可溶性白细胞介素2受体水平的动态观察及其临床意义 | |
| 引用本文： | 陆洪梅,吉布强,王桂东. 恶性淋巴瘤患者脑脊液可溶性白细胞介素2受体水平的动态观察及其临床意义[J]. 肿瘤研究与临床, 1998, 0(3) |
| 作者姓名： | 陆洪梅 吉布强 王桂东 |
| 作者单位： | 山东省临沂市肿瘤医院 |
| 摘 要： | 用双抗体夹心ＥＬＩＳＡ方法动态监测４６例恶性淋巴瘤（ＭＬ）患者脑脊液（ＣＳＦ）中可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平变化。发现ＭＬ患者脑脊液中ｓＩＬ－２Ｒ比正常人显著升高（Ｐ＜０．００１），且６例有中枢神经系统（ＣＮＳ）浸润者ｓＩＬ－２Ｒ与无ＣＮＳ浸润者相比有显著性差异（Ｐ＜０．０１）；而治疗达ＣＲ或ＰＲ后ｓＩＬ－２Ｒ显著降低（Ｐ＜０．０５），与正常人者相比Ｐ＞０．０５，脑脊液ｓＩＬ－２Ｒ水平与血清中ｓＩＬ－２Ｒ水平无显著相关性。认为动态监测ＭＬ患者脑脊液ｓＩＬ－２Ｒ水平有助于估价病变严重程度、ＣＮＳ有无浸润及疗效评定 |
| 关 键 词： | 可溶性白细胞介素2受体 恶性淋巴瘤 脑脊液 |
DYNAMIC OBSERVATION ON SOLUBLE INTERLUKIN 2 RECEPTOR OF CEREBROSPINAL FLUID IN PATIENTS WITH MALIGNANT LYMPHOMA AND ITS CLINICAL SIGNIFICANCE |
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| Lu Hongmei,Ji Buqiang,Wang Guidong Linyi Tumor Hospital. DYNAMIC OBSERVATION ON SOLUBLE INTERLUKIN 2 RECEPTOR OF CEREBROSPINAL FLUID IN PATIENTS WITH MALIGNANT LYMPHOMA AND ITS CLINICAL SIGNIFICANCE[J]. Cancer Research and Clinic, 1998, 0(3) | |
| Authors: | Lu Hongmei Ji Buqiang Wang Guidong Linyi Tumor Hospital |
| Abstract: | The serum and cerbrospinal fluid (CSF) levels of soluble interleukin 2 receptor (sIL 2R) before and after treatment in 46 patients with malignant lymphoma were determined. The data showed that the CSF sIL 2R levels in patients were significantly higher than that in control group, and the CSF sIL 2R levels of the six patients with CNS infiltration were significantly higher than those without CNS infiltration. The CNS sIL 2R levels of the trials were reduced remarkably after treatment. It is suggested that the CSF sIL 2R levels has clinical and prognostic significance in patients with malignant lymphoma. |
| Keywords: | Souble interleukin 2 receptor Malignant lymphoma Cerebrospinal fluid |
| 本文献已被 CNKI 等数据库收录！ | |