|
|||||
|
|
Effects of training and anabolic steroids on collagen synthesis in dog heart |
|
| Authors: | Timo E. S. Takala Pauliina Rämö Kai Kiviluoma Veikko Vihko Heikki Kainulainen Raimo Kettunen |
| Affiliation: | (1) Department of Sports Medicine, University of Oulu, Deaconess Institute of Oulu, SF-90100 Oulu, Finland;(2) Department of Physiology, University of Oulu, Oulu, Finland;(3) Department of Medical Biochemistry, University of Oulu, Oulu, Finland;(4) Research Unit for Sport and Physical Fitness, Jyväskylä, Jyväskylä, Finland;(5) Department of Clinical Sciences, University of Tampere, Tampere, Finland |
| Abstract: | Summary The effects of endurance training and anabolic steroid (Methandienone 1.5 mg · kg–1 p. o. daily) and their combination on regional collagen biosynthesis and concentration in the hearts of male beagle dogs were studied by measuring prolyl 4-hydroxylase (PH) activity and hydroxyproline (HYP) concentration. The PH (P<0.05) and HYP (P<0.05) were both greater in the subendocardinal layer than in the subepicardium (EPI) of the left ventricular wall in controls, whereas opposite gradients (P<0.05) were observed in the right ventricle. Endurance exercise caused an increase of PH activity in EPI of the left ventricular wall (P<0.01). The HYP concentration increased in both layers of the right ventricle in the exercise plus steroid group (P<0.05). The results suggest that transmural differences exist in the rate of collagen synthesis and concentration in canine cardiac ventricles and that endurance exercise may accelerate collagen synthesis in EPI of the left ventricle and the combination of exercise and anabolic steroid causes an increase in collagen concentration in the right ventricular wall. |
| Keywords: | Anabolic steorids Exertion Collagen Heart |
| 本文献已被 SpringerLink 等数据库收录！ | |