中西医结合治疗酒精性肝硬化并发肝性脑病25例临床观察

目的:探讨门冬氨酸鸟氨酸、纳洛酮联合醒脑静注射液对酒精性肝硬化并发肝性脑病的治疗作用.方法:酒精性肝硬化并发肝性脑病患者47例,分为治疗组25例,对照组22例.在常规综合治疗的基础上,对照组加用精氨酸、谷氨酸盐；治疗组加用门冬氨酸鸟氨酸、纳洛酮和醒脑静注射液.观察治疗组及对照组治疗前后的症状改善、血氨和肝功能指标,评价临床疗效.结果:治疗组血氨下降明显,治疗组总有效率高于对照组(88.00％ vs 63.64％,P＜0.05).2组患者治疗后血AST、ALT、GGT、TBIL均有不同程度的恢复,但均无统计学意义(P＞0.05).结论:门冬氨酸鸟氨酸、纳洛酮联合醒脑静注射液治疗酒精性肝硬化并发肝性脑病,能有效降低血氨,提高疗效.

Clinical observation of integrated medicine therapy for alcoholic cirrhosis complicated with hepatic encephalopathy

Objective:To investigate the therapeutic effect of omithine-aspartate and naloxone combined with Xingnaojing injection on alcoholic cirrhosis complicated with hepatic encephalopathy.Methods:Forty-seven patients with alcoholic cirrhosis complicated with hepatic encephalopathy were randomly divided into control group (n=22) and treatment group (n=25).The control group was treated with arginine and glutamate on the base of conventional treatment.The treatment group was treated with omithine-aspartate and naloxone combined with Xingnaojing injection on the base of conventional treatment.Improvement of symptoms,serum levels of ammonia and liver functions of two groups were observed and the clinical effect was evaluated.Results:The serum level of ammonia in treatment group was significantly decreased than that in the control group,and the total efficacy rate was higher in treatment group than that in control group (88.00% vs 63.64%,P<0.05).AST,ALT,GGT and TBIL showed various degrees of recovery after treatment in both groups,but without statistic significance (P>0.05).Conclusion:In treating alcoholic cirrhosis complicated with hepatic encephalopathy,Omithine-aspartate and naloxone combined with Xingnaojing injection are effective in down-regulating serum level of ammonia and can increase therapeutic effect.