Coronary Artery Disease in Patients ≥80 Years of Age |
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Authors: | Mahesh V Madhavan Bernard J Gersh Karen P Alexander Christopher B Granger Gregg W Stone |
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Institution: | 1. New York-Presbyterian Hospital and the Columbia University Medical Center, New York, New York;2. Mayo Clinic College of Medicine, Rochester, Minnesota;3. Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina;4. Cardiovascular Research Foundation, New York, New York |
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Abstract: | Coronary artery disease (CAD) is a major cause of morbidity and mortality in patients ≥80 years of age. Nonetheless, older patients have typically been under-represented in cardiovascular clinical trials. Understanding the pathophysiology, epidemiology, and optimal means of diagnosis and treatment of CAD in older adults is crucial to improving outcomes in this high-risk population. A patient-centered approach, taking into account health status, functional ability and frailty, cognitive skills, and patient preferences is essential when caring for older adults with CAD. The present systematic review focuses on the current knowledge base, gaps in understanding, and directions for future investigation pertaining to CAD in patients ≥80 years of age. |
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Keywords: | coronary artery disease geriatric cardiology octogenarians ACS acute coronary syndrome CABG coronary artery bypass graft CAC coronary artery calcium CAD coronary artery disease DES drug-eluting stent(s) GDMT guideline-directed medical therapy MACE major adverse cardiovascular event(s) MI myocardial infarction NSTEACS non–ST-segment elevation acute coronary syndrome PCI percutaneous coronary intervention SIHD stable ischemic heart disease STEMI ST-segment elevation myocardial infarction |
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