夏枯草化学成分的研究

目的：研究夏枯草(Prunella vulgaris L.)的化学成分。方法：用现代各种色谱方法分离夏枯草化学成分，用波谱技术鉴定结构。结果：从夏枯草的干燥果穗中分得6个化合物，经波谱(IR,UV,FAB-MS,1D and 2D-NMR)解析分别鉴定为3β,16α,24-三羟基齐墩果-12-烯-28-酸-3-O-(6′-丁酰基)-β-D-吡喃葡糖苷(I),乌苏酸(II),2α,3α-二羟基乌苏-12-烯-28-酸(III),槲皮素(IV),槲皮素-3-O-β-D-半乳糖苷(V)和咖啡酸乙酯(VI)。结论：I为新化合物，命名为夏枯草皂苷B(vulgarsaponin B)，III为首次从该植物中分离得到，V,VI为首次从该属植物中分离得到。

STUDIES ON THE CHEMICAL CONSTITUENTS FROM PRUNELLA VULGARIS

AIM： To find the chemical constituents of Prunella vulgaris L. METHODS: To separate the constituents of Prunella vulgaris by using various kinds of chromatography and identify their structures on the basis of spectral analysis. RESULTS: Six compounds were isolated from the spikes of Prunella vulgaris L. Their structures were established as 3β,16α,24-trihydroxyoleana-12-en-28-oic acid-3-O-(6′-butyryl)-β-D-glucopyranosid (I), ursolic acid (II), 2α,3α-dihydroxyurs-12-en-28-oic acid (III), quercetin (IV), quercetin-3-O-β-D-galactoside (V) and ethyl caffeate (VI) based on the analysis of spectral data of IR, UV, FAB-MS, 1D and 2D-NMR. CONCLUSION: I was a new compound, named vulgarsaponin B, III was isolated for the first time from this plant, V and VI for the first time from the Prunella genus.