恶性黑素瘤中BRAF癌基因突变研究新进展

恶性黑素瘤是死亡率较高的皮肤肿瘤之一,研究发现恶性黑素瘤中存在高频BRAF癌基因突变.紫外线是引起突变的高危因素,不同种族、发病部位以及病理类型的恶性黑素瘤间BRAF突变率存在差异.此突变与遗传、预先存在的色素痣、肿瘤侵袭性及预后之间的关系还存在争论.BRAF突变相关的MAPK信号传导分子是治疗恶性黑素瘤的靶点.综述近几年的研究,以认识BRAF突变与恶性黑素瘤的关系.

Mutation of BRAF gene in malignant melanoma:a review

Malignant melanoma(MM)is one of the most lethal skin cancer.High frequent mutation of v-raf murine sarcoma viral oncogene homolog B(BRAF)has been reported in MM,and ultraviolet is the most important risk factor of the mutation.The frequency of the mutation varies with races of patients,sites,and pathological types of MM.It's still controversial about the relationship of BRAF mutation with heredity,pre-existing pigment nevi,invasion and prognosis of MM.BRAF related molecules in MAPK signal transduction are potential treatment target of MM.Recent studies have revealed the association between BRAF mutation and MM.