益安宁治疗冠心病心绞痛60例临床观察

目的观察益安宁对冠心病心绞痛的治疗效果。方法90例冠心病心绞痛患者随机分为治疗组60例和对照组30例,分别给予益安宁和古方神力补治疗,治疗1个月后观察比较2组心绞痛症状、中医证候、心电图ST段、动态心电图、血脂、血液流变学等指标的变化。结果(1)在总体疗效方面,治疗组总有效率为91.7%,对照组总有效率为66.7%。经Ridit分析,2组差异有非常显著意义(P<0.01)。(2)在心电图方面,治疗组治疗前后心电图ST段有显著改善(P<0.01),对照组治疗前后ST段无显著改善(P>0.05),治疗后2组比较差异有非常显著意义(P<0.01)。(3)血液流变学方面,2组0S-1、5.0S-1、10.0S-1、35.0S-1、50.0S-1、红细胞聚集指数、红细胞变形指数、血小板粘附性、血小板聚集指数与治疗前比较差异均有显著意义(P<0.01或P<0.05);治疗组与对照组治疗后比较差异有显著意义(P<0.05);2组血浆黏度及红细胞压积治疗前后及组间比较均无显著性差异。(4)在血脂方面,2组治疗后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及氧化低密度脂蛋白(Ox-LDL)差异均有显著意义(P<0.01或P<0.05),且治疗组高密度脂蛋白胆固醇(HDL-C)升高有非常显著意义(P<0.01),而对照组治疗前后比较HDL-C及Ox-LDL无显著性差异。结论益安宁治疗冠心病心绞痛疗效明显优于古方神力补,症状改善、病情缓解、理化检查指标改善等方面明显优于古方神力补。

Effect of Yianning capsule on 60 cases of angina pectoris

Objective To study the effect of Yianning capsule on 60 cases of angina pectoris.Methods 90 cases with angina pectoris were randomly divided into two groups.60 cases with angina pectoris were treated with Yianning (treatment group),taken orally.2 times a day,18 pills each time;30 cases were treated with Gufangshenlibu (control group),taken orally,2 times a day,one little bottle each time.The changes of syndrome,ST segment of ECG,dynamic electrocardiogram,blood lipid and hemorheology were observed after 1 month's treatment.Results (1)The total effective rate (91.67%) in treatment group was significantly better than that (66.67%) in control group (P<0.01).(2)The ST segment of ECG was improved obviously in treatment group (P<0.01), but was not in control group, there was significant difference between two groups after treatment (P<0.01).(3)Evident changes of 0S~ -1 ,5.0S~ -1 ,10.0S~ -1 ,35.0S~ -1 ,50.0S~ -1 ,erythrocyte aggregation index,RBCs deformation index, platelets adhesion and platelets aggregation index were found in two groups after treatment (P<0.01 or P<0.05),but the changes in treatment group were more obviously than those in control group (P<0.05), there was no difference in plasma viscosity and hematocrit after treatment,also between two groups.(4)blood lipids, The TC,TG and LDL-C decreased in two groups (P<0.01 or P<0.05),Ox-LDL decreased and HDL-C increased in treatment group after treatment (P<0.01 or P<0.05), but there was no significant change of Ox-LDL and HDL-C in control group after treatment.Conclusion The effects of Yianning capsule on angina pectoris is better than those of Gufangshenlibu.