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| 不同剂量紫杉醇联合卡铂一线治疗晚期非小细胞肺癌的临床研究 | |
| 引用本文： | 钱嘉琳,沈洁,白皓,韩宝惠. 不同剂量紫杉醇联合卡铂一线治疗晚期非小细胞肺癌的临床研究[J]. 中国肺癌杂志, 2011, 14(4): 323-328. DOI: 10.3779/j.issn.1009-3419.2011.04.04 |
| 作者姓名： | 钱嘉琳 沈洁 白皓 韩宝惠 |
| 作者单位： | 上海交通大学附属胸科医院肺内科,上海,200030 |
| 摘 要： | 背景与目的紫杉醇联合卡铂一线治疗晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)临床应用较为广泛。本研究旨在比较不同剂量紫杉醇联合卡铂一线治疗晚期NSCLC患者的毒副反应及疗效。方法 2006年12月-2008年6月,共63例晚期NSCLC患者接受紫杉醇175mg/m2或200mg/m2联合卡铂(AUC5)化疗,前者42例,后者21例,ECOG评分0-1分,3周-4周重复,比较两组近期和远期疗效及毒副反应。结果紫杉醇175mg/m2与200mg/m2化疗组客观有效率分别为28.57%与33.33%(P=0.698),中位P为6.7个月与7个月(P=0.561),MST为18.7个月与19个月(P=0.255),1年生存率为61.9%与66.7%(P=0.711),2年生存率为31%与33.3%(P=0.852)。紫杉醇200mg/m2组3/4级中性粒细胞下降发生率明显高于175mg/m2组,分别为61.9%与33.3%(P=0.031)。结论与200mg/m2化疗组相比,紫杉醇175mg/m2联合卡铂一线治疗晚期NSCLC患者可明显减少3/4级中性粒细胞下降发生率,且疗效及生存期并不劣于较高剂量化疗组。 |
| 关 键 词： | 肺肿瘤 化疗 紫杉醇 卡铂 |
The Clinical Analysis of Paclitaxel at Two Dose Levels plus Carboplatin as the First-line Treatment in Advanced Non-small Cell Lung Cancer |
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| Jialin QIAN,Jie SHEN,Hao BAI,Baohui HAN. The Clinical Analysis of Paclitaxel at Two Dose Levels plus Carboplatin as the First-line Treatment in Advanced Non-small Cell Lung Cancer[J]. Chinese journal of lung cancer, 2011, 14(4): 323-328. DOI: 10.3779/j.issn.1009-3419.2011.04.04 | |
| Authors: | Jialin QIAN Jie SHEN Hao BAI Baohui HAN |
| Affiliation: | Jialin QIAN,Jie SHEN,Hao BAI,Baohui HAN Department of Pulmonary Medicine,Shanghai Chest hospital,Shanghai Jiaotong University,Shanghai 200030,China |
| Abstract: | Background and objective The combination of pacilitaxel and carboplatin has become a widely used regimen in first-line therapy of advanced NSCLC. The aim of this study is to compare the efficacy and safety of paclitaxel plus carboplatin at two dose levels in the first-line treatment of advanced NSCLC patients. Methods From Dec 2006 to Jun 2008,63 patients(ECOG 0-1) with advanced NSCLC were administered with paclitaxel 175 mg/m2(42 patients) plus carboplatin(AUC 5) or paclitaxel 200 mg/m2(21 patients) plus c... |
| Keywords: | Lung neoplasms Drug therapy Paclitaxel Carboplatin |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |