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A cytotoxic anti HLA-AB monoclonal antibody which in dilution becomes specific to HLA-A3 crossreacting group |
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| Authors: | M. C. Mazzilli I. Cascino S. Costanzi Porrini M. V. Lavaggi P. Lulli M. Morellini L. Testa E. Gandini |
| Affiliation: | Cattedra di Genetica Medica, Universitàdi Roma "La Sapienza" |
| Abstract: | XI 20.4 monoclonal antibody belongs to the IgM class. It precipitates two polypeptide chains characteristic of HLA Class I antigens. At the highest dilutions it is cytotoxic against lymphocytes carrying antigens of the HLA-A3 crossreacting group. Lysostrip experiments show that, at the lowest dilutions, the antibody reacts either with HLA-A, or B antigens. |
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