新生儿呼吸衰竭时氧交换指标监测的临床意义

目的探讨新生儿呼吸衰竭时氧交换指标动态监测在临床的意义。方法对新生儿重症监护病房接受呼吸机治疗的120例呼吸衰竭新生儿,予行血气、动脉氧分压与吸入氧浓度之比、动脉/肺泡氧分压比值、肺泡-动脉氧分压差、呼吸指数等指标的动态监测,并根据其病情分组进行对比观察。结果轻度呼吸衰竭组与重度呼吸衰竭组两组间各项氧交换指标均有显著性差异(P<0.05);生存组治疗前与治疗24h后的氧交换指标比较,有非常显著性差异(P<0.001);死亡组治疗前与治疗24h后动脉/肺泡氧分压比值变化差异无显著性(P>0.05)。结论应用氧交换指标对呼吸衰竭的新生儿进行临床评估,对判断病情、指导治疗和估计预后有重要意义。

Clinical significance of monitoring indexes of oxygen exchange in neonate with respiratory failure

Objective To study the clinical significance of monitoring indexes of oxygen exchange in the neonates with respiratory failure.Methods 120 neonates with respiratory failure treated with ventilator in neonatal intensive care unit were detected for arterial blood gas to calculate PaO_2/FiO_2,PaO_2/PAO_2,A-aDO_2 and RI,these neonates were divided into four groups according to the severity of illness.Results There was significantly difference for the indexes of oxygen exchange in the moderate and severe respiratory failure between the two groups(P<0.05).There was significantly difference for the indexes of oxygen exchange in the survival group before the treatment and after 24 hours of treatment respectively(P<0.001).As to the results of PaO_2/PAO_2,there was no significant difference in the death group before the treatment and after 24 hours of treatment respectively (P>0.05).Conclusion The clinical evaluation by these indexes of oxygen exchange for newborn with respiratory failure is beneficial in judging the severity of illness,guiding therapy and evaluating prognosis.