| 层粘连蛋白和纤维粘连蛋白在着床期小鼠子宫内膜中的表达 |
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| 引用本文： | 郝晶,高英茂,武玉玲,宋卫华,邴鲁军. 层粘连蛋白和纤维粘连蛋白在着床期小鼠子宫内膜中的表达[J]. 解剖学杂志, 2001, 24(1): 28-32 |
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| 作者姓名： | 郝晶 高英茂 武玉玲 宋卫华 邴鲁军 |
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| 作者单位： | 山东医科大学组织学与胚胎学教研室,;山东医科大学组织学与胚胎学教研室,;山东医科大学组织学与胚胎学教研室,;山东医科大学组织学与胚胎学教研室,;山东医科大学组织学与胚胎学教研室, |
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| 摘 要： | 目的：为探讨层粘连蛋白和纤维粘连蛋白在胚泡着床过程中的生物学作用。方法：本实验使用昆明雌性小鼠30只,分为未孕和早期妊娠共6组。通过免疫组织化学方法,检测了层粘连蛋白和纤维粘连蛋白在着床期小鼠子宫内膜中的分布状况。结果：胚泡着床开始时（即受精后4－5天）,层粘连蛋白和纤维粘连蛋白均出现一个表达高峰,尔后纤维粘连蛋白迅速减少。受精后6－8天,细胞外基质中的层粘连蛋白逐渐增加。结论：层粘连蛋白和纤维粘连蛋白在胚泡着床微环境和植入调节中发挥重要作用。
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| 关 键 词： | 层粘连蛋白 纤维粘连蛋白 着床 子宫 子宫内膜 |
CHANGES OF LAMININ AND FIBRONECTIN EXPRESSSION IN MURINE ENDOMETRIUM DURING IMPLANTATION |
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| Hao Jing,Gao Yingmao,Wu Yuling,SONG Weihua,Bing Lujun. CHANGES OF LAMININ AND FIBRONECTIN EXPRESSSION IN MURINE ENDOMETRIUM DURING IMPLANTATION[J]. Chinese Journal of Anatomy, 2001, 24(1): 28-32 |
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| Authors: | Hao Jing Gao Yingmao Wu Yuling SONG Weihua Bing Lujun |
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| Abstract: | To study the effect of laminin and fibronectin in the process of implantation. Methods:Thirty Kuming female mice were divided into a unpregnant group and 5 early pregnant group. The distribution of laminin ( LN ) and fibronectin (FN) in endometrium were observed with immunohistochemical method. Results: The expression of LN and FN peaked at the beginning of implantation(day 4～ 5 of pregnancy), then FN decreased suddenly. LN in extracellular matrix(ECM)around decidual cells increased gradually. Conclusion: LN and FN in endometrium may play a critical role in construction of microenviroment for embryo implantation, and may also he an important regulator in the process of implantation. |
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| Keywords: | laminin fibronectin implantation uterus endometrium |
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