妊娠肝内胆汁淤积症患者胎盘组织中血管内皮生长因子的表达

目的观察血管内皮生长因子(VEGF)在妊娠肝内胆汁淤积症(ICP)胎盘中的表达.方法采用免疫组织化学方法,检测25例正常妊娠胎盘(对照组)和25例ICP胎盘(ICP组)中VEGF的水平.结果 VEGF在正常妊娠胎盘和ICP胎盘中分布基本一致,分布在滋养细胞、血管及绒毛间质.在ICP组VEGF为轻度表达占76%,中度表达占24%,无重度表达;而在对照组VEGF轻度表达占24%,中度表达占44%,重度表达占32%.ICP组中VEGF表达明显低于对照组(P＜0.01).结论 VEGF在胎盘中主要由绒毛滋养细胞分泌,ICP胎盘中VEGF的减少可能与胎盘血管生成减少及胎盘滋养叶细胞浸入异常有关,在ICP发病中占有一定的地位.

Expression of vascular endothelial growth factor in Placenta from pregnancy complicated with intrahepatic cholestasis of Pregnancy

Objective To investigate the expression of vascular endothelial growth factor (VEGF)in Placenta from Patients with intrahepatic cholestasis of Pregnancy (ICP).Methods The expression of VEGF in 25 Placentas from normal pregnancy(normal group)and 25 placentas from ICP(ICP group)is detected by immuno-histochemistry. Results The distribution of VEGF in Placenta of normal group is similar to that of ICP group.They are all found in Villous trophoblast,villous blood vessels and villous strome.VEGF is light expressed mostly in placenta of ICP group about 76%,the moderate is 24% and there is no strong exprssion,ln normal placenta light expression is only 24%,the moderate is 44% and strong is 32%.The level of VEGF was significanly lower in ICP group than that in normal group(P<0.01).Conclusions These results suggest that VEGF is secreted mainly by syncytiotrophoblast in buman placenta.The decrase of VEGF in placenta from ICP may be related to inade-quate blood vessel for mation and the abnormal invasions of tropho-blast and may play a rule in the cause of ICP.