3岁前有和无睡眠障碍孤独症儿童临床症状的比较分析

目的比较3岁前有无睡眠障碍孤独症儿童临床症状及发展特点。方法对1999—2006年在北京星星雨教育研究所接受特殊教育的275例孤独症学生进行儿童期孤独症评定量表(CARS)、克氏行为量表(CABS)测量。结果总体上3岁前有过睡眠障碍者症状严重于无睡眠障碍者。2~4岁时，有过睡眠障碍者比无睡眠障碍者病情严重，如有过睡眠障碍者情感、感觉、行为、社交问题均比无睡眠障碍者严重；5~8岁时，两者病情严重程度却比较接近，且有过睡眠障碍患儿情感反应优于无睡眠障碍患儿。结论3岁前有过睡眠障碍者与无睡眠障碍者有着不同的病情发展模式。前者起始症状严重，随后病情进展缓慢；后者起始症状虽然较轻，但病情进展迅速，以至于两类患者在学龄初期时病情严重程度基本相当。

Comparison and analysis of clinical symptoms of autistic children with or without sleep disorders in children before 3 years old.

Objectives To study the correlation of in vitro fluconazole susceptibility with clinical outcome for complicated vulvovaginal candidiasis(VVC). Methods Niniety-two cases of outpatients with complicated VVC were investigated at Shenzhen Hospital of Peking University between June and September 2005.All strains were identified with API Candida system. Fluconazole susceptibility was tested using E test. The patients were treated with fluconazole 150mg at day 1 and day 4. Eradication or failure was refered candida negative or positive in microscopic examination. Results The age of the patients was 29.87 years old. The mycologic cure rate of the patients at day 7-10 and day 30-35 was 85.9%(79/92 cases) and 71.7%(66/92 cases), respectively. The susceptibility rate of candida species for fluconazole was higher at day 7-14 and day 30-35 in cured group than failed group(93.8%,76/81 strains vs 61.5%,8/13 strains and 94.1%,64/68 strains vs 76.9%,20/26 strains), P<0.05.The susceptible-dose-dependent rate of candida species for fluconazole was lower in cured group than failed group ( 4.9%,4/81 strains vs 38.5%,5/13 strains and 4.4%,3/68 strains vs 23.1%,6/26 strains),P<0.05.The resistance rate of candida species for fluconazole were similar at day 7-14 and day 30-35 in cured group and failed group(1.3%,1/81 strains vs 0,0/13 strains and 1.5%,1/68 strains vs 0,0/26 strains), P>0.05.Conclusion The decrease of susceptibility rate of candida species for fluconazole is the cause of therapeutic failure.