|
|||||
|
|
Pontine myelinolysis following liver transplantation: a report of two cases |
|
| Authors: | S. Winnock G. Janvier F. Parmentier B. Duche P. Daverat C. Combe A. Vallet C. Douws J. Carles J. Saric |
| Affiliation: | (1) Department of Anesthesia, Pellegrin University Hospital, Place Amélie Raba-Léon, F-33076 Bordeaux Cedex, France;(2) Department of Neurology, Pellegrin University Hospital, Place Amélie Raba-Léon, F-33076 Bordeaux Cedex, France;(3) Department of Rehabilitation, Pellegrin University Hospital, Place Amélie Raba-Léon, F-33076 Bordeaux Cedex, France;(4) Department of Nephrology, Pellegrin University Hospital, Place Amélie Raba-Léon, F-33076 Bordeaux Cedex, France;(5) Department of Radiology, Pellegrin University Hospital, Place Amélie Raba-Léon, F-33076 Bordeaux Cedex, France;(6) Department of Surgery, Saint-André University Hospital, Bordeaux, France |
| Abstract: | Two cases of central pontine myelinolysis (CPM) following orthotopic liver transplantation (OLT) are reported. Several months after the onset of this neurological syndrome, the two patients are still alive but with severe neurological sequelae. Some patients undergoing emergency OLT present a high risk of CPM because of pre-existing malnutrition, encephalopathy, and hepatic insufficiency. All of these are associated with an inevitable abrupt rise in sodium serum concentration due to intraoperative compensation of blood losses with high-sodium content blood products. Whenever the renal capacity to excrete sodium is impaired by the surgical procedure, continuous intraoperative venouvenous hemofiltration is recommended. |
| Keywords: | Myelinolysis liver transplantation — Pontine myelinolysis liver transplantation — Liver transplantation pontine myelinolysis |
| 本文献已被 SpringerLink 等数据库收录！ | |