同种异体骨移植治疗骨缺损的临床应用

目的 观察异体骨移植治疗骨缺损的临床疗效。方法 21例骨缺损病人，年龄7至56岁，创伤性骨缺损15例，肿瘤性骨缺损6例，采用山西省医用组织库提供的同种异体骨移植，其中大段骨移植1例，骨块 骨条移植11例，骨条移植9例，术后观察切口愈合等级，免疫排斥反应的表现，骨缺损愈合情况及异体骨移植的并发症。结果 21例病人随访2至18个月，切口甲级愈合16例，乙级愈合4例，术后感染丙级愈合1例。移植骨愈合19例，移位骨部分吸收1例，1例随访时间65天，移植骨尚未愈合。结论 小块异体骨移植可获得自体骨移植的同样疗效，未观察到明显的免疫排斥反应，大段骨移植疗效尚待观察。

Clinical application of allograft in the treatment of bone defects

s objective To investigate the clinical effects of allograft in the treatment of bone defects.Methods:21 cases of patients including 15 cases of traumatic bone defects and 6 cases of tumorous bone defects,aged 7 to 56 years old,were treated by allograft which come from Medical Tissue Bank of Shanxi Province in china,in which 1 case of long segmental allograft?11 cases of bone block and bone strip allograft and 9 cases of bone strip allograft postoperative wound union?manifestation of immuno-rejection?union of bone defects and complication were observed.Results:21 cases were followed for 2 to 18 months.incision union of the first rate happened in 16 case,the second rate in 4 cases and 1 case showed postoperative infection of wound.19 cases displayed union of allograft and 1 case showed segmental resorption.1 case was followed for 65 days,butnon-union happened.Discussion:Small piece of allograft can receive the same therapeutic results as that of autograft and no obvious immuno-rejection was found.The effect oflarge segmental allograft is waiting for observation.