| 毛菊苣的化学成分 |
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| 引用本文： | 杨文志,汪豪,尚靖,冯锋,谢宁.毛菊苣的化学成分[J].中国天然药物,2009(3):193-195. |
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| 作者姓名： | 杨文志 汪豪 尚靖 冯锋 谢宁 |
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| 作者单位： | [1]中国药科大学天然药物化学教研室,南京210009 [2]中国药科大学新药筛选中心,南京210038 |
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| 基金项目： | 【基金项目】国家科技支撑计划项目;维吾尔医药的现代化研究与产业化示范（No.2007BA130802） [Foundation Item] This project was supported by the National Science ＆Technology Supporting Planned Project and Modernization Research and Industrialization Demonstration of the Uighur Medicine （No. 2007BAI30B02）. |
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| 摘 要： | 目的：对毛菊苣地上部分的化学成分进行研究。方法：运用多种柱层析方法进行分离纯化, 通过 1H, 13C NMR等波谱技术进行结构鉴定。结果：从毛菊苣地上部分的乙酸乙酯和正丁醇部位分离得到了11个化合物, 分别鉴定为莴苣苦素（1）,山莴苣苦素（2）,七叶内酯（3）,菊苣苷（4）,槲皮素-3-O-β-D-葡萄糖醛酸苷（5）,山柰酚-3-O-β-D-葡萄糖醛酸苷（6）,异槲皮苷（7）,异鼠李素（8）,槲皮素（9）,肌苷（10）,对羟基苯甲酸 （11）。结论：化合物4-11为首次从毛菊苣中分得,5-6,8-11为首次从菊苣属中分得。
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| 关 键 词： | 毛菊苣 菊科 化学成分 |
Chemical Constituents from Cichorium glandulosum |
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| YANG Wen-Zhi,WANG Hao,SHANG Jing,FENG Feng,XIE Ning.Chemical Constituents from Cichorium glandulosum[J].Chinese JOurnal of Natural Medicines,2009(3):193-195. |
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| Authors: | YANG Wen-Zhi WANG Hao SHANG Jing FENG Feng XIE Ning |
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| Institution: | 1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009 2Center for New Drug Screening, China Pharmaceutical University, Nanjing 210038) |
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| Abstract: | AIM： To investigate the chemical constituents from the aerial parts of Cichorium glandulosum Boiss. et Huet. METHODS： Various column chromatographic methods were applied for the isolation and purification of the chemical constituents and their structures were elucidated on the basis of 1H and 13C NMR spectroscopic techniques. RESULTS： Eleven compounds were isolated and identified as lactucin （1）, lactucopicrin （2）, esculetin （3）, cichoriin （4）, quercetin-3-O-β-D-glucuronide （5）, kaempferol-3-O-β-D-glucuronide （6）, isoquercitrin （7）, isorhamnetin （8）, quercetin （9）, inosine （10） and p-hydroxybenzoic acid （11）. CONCLUSION： Compounds 4-11 were obtained from this plant firstly and compounds 5-6, 8-11 were isolated from this genus for the first time. |
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| Keywords: | Cichorium glandulosum Compositae Chemical constituents |
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