| 大鼠口服木通皂苷D粪便中代谢物的HPLC-MS^n分析 |
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| 引用本文： | 李凯,杨小林,张春凤,杨中林.大鼠口服木通皂苷D粪便中代谢物的HPLC-MS^n分析[J].中国天然药物,2009(6):440-443. |
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| 作者姓名： | 李凯 杨小林 张春凤 杨中林 |
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| 作者单位： | [1]中国药科大学现代中药教育部重点实验室,南京210009 [2]武汉工业学院生物与制药工程系,武汉430023 |
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| 基金项目： | 国家自然科学基金重点项目（No.30730113） |
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| 摘 要： | 目的：研究木通皂苷D在大鼠粪便中的代谢物。方法：灌胃木通皂苷D（400mg·kg^-1）后收集粪样，运用高效液相色谱和质谱联用技术检测木通皂苷D的代谢产物。结果：在给药后大鼠的粪便中，发现并初步鉴定了5个主要代谢产物的化学结构。结论：大鼠口服给予木通皂苷D后，在粪便中的主要代谢产物为3-O—α-L-吡喃阿拉伯糖基-常春藤皂苷元-28-β-D-吡喃葡萄糖酯苷、常春藤皂苷元-28-β-D-吡喃葡萄糖酯苷、3-O—α-L-吡喃阿拉伯糖基-常春藤皂苷元、常春藤皂苷元及常春藤皂苷元-28-O-β-D-吡喃葡萄糖基（1→6）-β-D-吡喃葡萄糖苷。
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| 关 键 词： | 木通皂苷D 粪便 代谢物 HPLC—MS^n |
Metabolites of Asperosaponin VI in Rats＇ Feces by HPLC-MS^n |
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| LI Kai,YANG Xiao-Lin,ZHANG Chun-Feng,YANG Zhong-Lin.Metabolites of Asperosaponin VI in Rats＇ Feces by HPLC-MS^n[J].Chinese JOurnal of Natural Medicines,2009(6):440-443. |
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| Authors: | LI Kai YANG Xiao-Lin ZHANG Chun-Feng YANG Zhong-Lin |
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| Institution: | 1Key Laboratory of Modern Chinese Medicines Ministry of Education, China Pharmaceutical University, Nanjing 210009; 2Department of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China) |
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| Abstract: | AIM： To investigate the metabolites of asperosaponin VI in rats＇ feces. METHODS： Feces were collected after oral administration of 400 mg·kg^-1 asperosaponin Ⅵ to rats. The samples were detected by LC-MSn method. RESULTS： Major metabolites were found in rat feces and their chemical structures were identified primarily. CONCLUSION： The metabolites found in feces were 3-O-α-L-arabinopyranosyl hederagenin-28-β-D- glucopyranoside, hederagenin-28-β-D-glucopyranoside, 3-O-α-L-arabinopyranosyl hederagenin, hederagenin, hederagenin-28-β-D-glucopyranoside-（1→6）-β-D-glucopyranoside. |
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| Keywords: | Asperosaponin VI Feces Metabolites HPLC-MSn |
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