高强度聚焦超声治疗兔肾VX2肿瘤的实验研究

目的探讨高强度聚焦超声（ＨＩＦＵ）治疗肾肿瘤的效果。方法采用兔肾ＶＸ２肿瘤模型进行ＨＩＦＵ辐照。辐照后不同时期处死动物以观察其病理变化。另以辐照组及对照组动物各６只，于２周后处死，比较肿瘤生长及肺转移的情况。结果ＨＩＦＵ辐照后肿瘤细胞立即发生凝固性坏死，电镜下亦见到不可逆的破坏。２周后有４只动物的肿瘤原发灶已被完全破坏；另２只靶区外有少量肿瘤残存，其体积为６２．８ｍｍ３和９．４ｍｍ３，而对照组的肿瘤平均体积为（１７５１．１±３５３．７）ｍｍ３。辐照组有２只（３３％）发生肺转移，转移结节数为９和３；对照组全部发生肺转移，转移结节数为５２±３４。两组差异有显著性。结论ＨＩＦＵ对兔肾ＶＸ２肿瘤有很强的杀伤作用。

An experimental study on high intensity focused ultrasound in the treatment of VX2 rabbit kidney tumors

Objective To investigate the effectiveness of high intensity focused ultrasound(HIFU) in the treatment of kidney tumors. Methods Fourteen New Zealand rabbits bearing VX2 kidney tumors were irradiated with HIFU at an intensity of 1200W/cm2 for 2 consecutive periods of 90s. Six other tumorbearing rabbits served as controls. The treated rabbits were sacrificed at different periods after irradiation to observe the pathological changes. Six of the treatment and the control group each were killed on the 14th day to study the growing condition of the primary tumors and the status of lung metastasis. Results Tumor cells underwent coagulation necrosis immediately after irradiation with HIFU. Irreversible destruction was observed under electron microscope. The primary tumors in 4 rabbits of the treatment group had been completely eradicated; while in the other two,one residual tumor was found beyond the target area in each rabbit. The size of the residual tumors was 62.8mm3 and 9.4mm3, while the average size of the primary tumors in the control group was 1 751.1353.7mm3.Lung metastasis took place in 2 rabbits of the treatment group,with 9 and 3 metastatic nodules respectively. Lung metastasis occured in all the control animals.The number of metastatic nodules was 5234. The difference between these two groups was significant. Conclusions HIFU should be effective in the treatment of kidney tumors.