血液灌流治疗急性重度有机磷中毒的疗效观察

目的 探讨血液灌流治疗急性重度有机磷中毒的临床疗效.方法 将本院收治的72例急性重度有机磷中毒患者随机分为3组,每组24例;对照组采取内科常规性治疗,治疗组在常规内科治疗后给予血液灌流治疗,强化治疗组在常规内科治疗的同时给予早期强化血液灌流治疗;比较3组患者临床疗效及并发症发生情况的差异.结果 血液灌流治疗可显著降低长托宁使用剂量和临床并发症发生率,缩短机械通气时间、胆碱酯酶恢复时间及意识恢复时间(P＜0.05);早期强化血液灌流可进一步提高急性重度有机磷中毒的临床疗效,降低临床并发症发生率(P＜0.05).结论 早期强化血液灌流治疗能够显著提高急性重度有机磷中毒的临床疗效,降低临床并发症发生率,改善患者的预后,值得临床推广.

Hemoperfusion for acute severe organophosphorus poisoning

Objective To explore the clinical effect of hemoperfusion for patients with acute rganophosphorus poisoning.Methods 72 patients with acute severe organophosphorus poisoning treated at our hospital were randomly divided into three groups,24 cases for each group.The control group were routinely treated;in addtition,the treatment group were treated with hemoperfusion and the intensive treatment group with early intensive treatment and hemoperfusion.The clinical curative effect and the incidences of complications were compared between these three groups.Results Hemoperfusion could significantly reduce the dose of penehyclidine hydrochloride and the incidence of clinical complications,shorten mechanical ventilation time,and the recovery times of cholinesterase and consciousness (P＜0.05);Early intensive treatment of hemoperfusion could further improve the clinical efficacy and decarese the incidence of clinical complications (P＜0.05).Conclusions Early intensive treatment of hemoperfusion can significantly improve the clinical curative effect for acute severe organophosphate poisoning,decrease the incidence of complications,and improve the patients' prognosis,so it is worth being clinically generalized.