肾上腺皮质肿瘤增殖活性检测及预后意义

 目的：探讨细胞增殖活性检测对肾上腺皮质肿瘤的诊断价值和预后。方法：采用DNA含量测定、AgNOR和PCNA染色对正常肾上腺皮质、皮质增生、腺瘤和癌进行细胞增殖活性检测。结果：正常肾上腺与皮质增生DNA含量、AgNOR计数、PCNA指数均值相接近(P>0.05)，DNA倍体主要呈二倍体。腺瘤较增生组相比三种指标均值相差显著(P<0.01)。结论：提示细胞增殖活性检测对肾上腺皮质肿瘤诊断和预后判断有较大参考价值。

The Proliferative Activity Detection in Adrenocortical Neoplasms and Their Clinical Significance

The cell proliferative activity of normal,hyperplasia,adenoma and carcinoma in adrenal cortex were detected by using DNA cytophotometry,AgNOR and PCNA staining.The results showed:the average value of DNA contents,AgNOR counts and PCNA LI were no difference between normal and hyperplasia in adrenal cortex( P>0 05) .Their DNA ploidy presented mainly diploid.Between adenomas and hyperplasia,3 kinds of average value were significant difference( P<0 01 ).The DNA ploidy of adenomas were often diploid and euploid,their AgNOR counts and PCNA LI were small and prognosis were better.In carcinomas,3 kinds of average value remarkably increased( P<0 01) .The DNA ploidy presented non euploid(3 cases)and aneuploid(5 cases),the AgNOR counts and PCNA LI of the latter increased,their prognosis were poor.These indicated that cell proliferative activity detection have diagnosis and prognosis value in adrenocortical neoplasms.