GLOMERULAR LESIONS IN MULTIPLE MYELOMA |
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| Authors: | Tsuyoshi Tange Katsumaro Kurumado Masaki Nakazawa Yukio Imamura Kinori Kosaka Akira Kawaoi |
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| Affiliation: | Department of Pathology, Faculty of Medicine, University of Tokyo, Tokyo;Department of Internal Medicine, National Medical Center Hospital, Tokyo;Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo;Department of Pathology, Faculty of Medicine, Nihon University, Tokyo |
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| Abstract: | ![]()
An autopsy case of multiple myeloma (IgG, lambda type), clinically characterized by decreased glomerular filtration rate, is reported with particular emphasis on changes in the glomeruli of kidneys. Histologically, the glomeruli revealed slight increase in mesangial matrix and focal thickening of tuft capillary wall. Electron-microscopically, deposits were observed in a subendothelial location in the glomerular capillary walls, and inclusions were noted in the cytoplasm of the visceral epithelial cells. Histoimmunofluo-rescent study of the kidney demonstrated intense focal and slight diffuse positivity against labelled antisera of anti-IgG and anti-lambda type of light chain on the capillary wall of the glomerular tufts. Other immunoglobulins were not demonstrable in capillary walls. These findings represent the intraglomerular deposition of paraprotein of multiple myeloma without amyloidosis. |
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