Evolution of the sperm aster after microinjection of isolated human sperm centrosomes into meiotically mature human oocytes |
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Authors: | Van Blerkom Jonathan; Davis Patrick |
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Institution: | Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, CO 80309 Reproductive Genetics In Vitro, Denver CO 80222, USA |
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Abstract: | This study examined the feasibility of isolating and transferringthe centrosome-containing region of spermatozoa to mature humanoocytes. The findings demonstrate that individual sperm centrosomescan be transferred and are capable of nucleating maternal tubulinto form a well-developed sperm aster in the recipient oocyte.The results are discussed with respect to centrosome functionin early human development and applications in clinical in-vitrofertilization in the treatment of certain forms of male factorinfertility. |
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Keywords: | microinjection/sperm aster/sperm centrosome |
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