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| 人尿中曲马多及其代谢物的分析 | |
| 引用本文： | 徐友宣,徐妍青,张长久,申利. 人尿中曲马多及其代谢物的分析[J]. 药学学报, 1993, 28(5): 379-383 |
| 作者姓名： | 徐友宣 徐妍青 张长久 申利 |
| 作者单位： | 国家体委运动医学研究所兴奋剂检测中心，中国医学科学院药物研究所，国家体委运动医学研究所兴奋剂检测中心，国家体委运动医学研究所兴奋剂检测中心 北京 100029，北京 100050，北京 100029，北京 100029 |
| 摘 要： | 用GC-MS方法分析了人尿中的曲马多及其代谢产物。分析步骤:尿用酸解、醚洗及二氯甲烷—异丙醇混合溶剂提取,挥干后用MSTFA-MBTFA衍生化,然后于GC-MSD上进样分析,在服药后40 h内的尿中可检出原型及4个代谢物,在40～60 h内只能检出原型。本法对原型药物的回收率为85.2%,检测限可达12.5 pg。 |
| 关 键 词： | 曲马多 气相色谱—质谱 |
| 收稿时间： | 1992-10-26 |
ANALYSIS OF TRAMADOL AND ITS METABOLITES IN HUMAN URINE |
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| YX Xu,YQ Xu,CJ Zhang and L Shen. ANALYSIS OF TRAMADOL AND ITS METABOLITES IN HUMAN URINE[J]. Acta pharmaceutica Sinica, 1993, 28(5): 379-383 | |
| Authors: | YX Xu YQ Xu CJ Zhang L Shen |
| Abstract: | A G-C-MS method for the analysis of tramadol and its four metabolites in human urine is described. The urine samples were acid hydrolyzed with hydrochloric acid, cleaned with diethyl ether and extracted with dichloromethane—isopropanol (9:1). After derivatization, the solution was analyzed with GC-MSD. Tramadol and its 4 metabolites were detected in urine samples 2～40 hours after oral administration. The recovery of tramadol was 85.2%±5.4(n=3), the detection limit was down to 12.5 pg. The derivatization methods was discussed. |
| Keywords: | Gas chromatography—mass spectrometry Tramadol |
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