肠易激综合征流行病学研究现状与进展

肠易激综合征(irritable bowel syndrome,IBS)是一种以慢性或者反复发作的腹痛伴排便习惯改变为特征的功能性肠病,并缺乏形态学和生化标志的异常。IBS是一种全球性疾病,人群患病率较高,其症状可反复发作,严重影响患者的生活质量,并占用了大量的医疗资源。IBS的病因和发病机制尚未明了,随着对IBS认识的不断深入和发展,国内外在不同时期,采用不同的标准和方法,对IBS的流行病学进行了较深入的研究,但不同国家和地区、不同人群的IBS患病率及其分布特征研究结果不尽相同,影响IBS的危险因素主要包括社会心理因素及遗传、感染、食物、药物因素等,现就近年来国内外IBS流行病学的研究情况作一综述。

The epidemiology of irritable bowel syndrome

Irritable bowel syndrome(IBS) is a highly prevalent gastrointestinal motility disorder broadly characterized by abdominal pain/discomfort associated with altered bowel habits and absence of abnormal morphological,histological or inflammatory markers.The chronic and bothersome nature of IBS symptoms often negatively affects patients quality of life and activity level and places a substantial economic burden on patients and the healthcare system.Irritable bowel syndrome has been described as a biopsychosocial condition,in which colonic dysfunction is affected by psychological and social factors.As a result of this unusual constellation,irritable bowel syndrome may be subject to cultural variables that differ in different parts of the globe.Distribution and risk factors of irritable bowel syndrome have been reported variously,so we review the epidemiology and current understanding of the risk factors of irritable bowel syndrome from published material.