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| 肺移植术后急性细胞介导排斥反应的诊疗新进展 | |
| 引用本文： | 徐钰, 练巧燕, 陈奥, 等. 肺移植术后急性细胞介导排斥反应的诊疗新进展[J]. 器官移植, 2021, 12(5): 614-618. doi: 10.3969/j.issn.1674-7445.2021.05.017 |
| 作者姓名： | 徐钰 练巧燕 陈奥 张建恒 徐鑫 韦兵 蔡宇航 黄丹霞 邝敏婷 何建行 巨春蓉 |
| 作者单位： | 510012 广州医科大学附属第一医院广州呼吸健康研究院 呼吸疾病国家重点实验室 |
| 基金项目： | 广东省钟南山医学基金会ZNSA-2020013 广州呼吸健康研究所基金2019GIRHZ04 |
| 摘 要： |  急性细胞介导排斥反应(ACR)是肺移植术后常见的并发症，主要是由T淋巴细胞识别移植物细胞表面的主要组织相容性复合体引发的免疫反应，目前被认为是急性排斥反应的主要形式。ACR不仅可以直接导致受者死亡，也是肺移植术后慢性排斥反应的高危因素。但肺移植术后ACR的诊断困难，治疗棘手。本文总结了肺移植受者ACR的危险因素、发病机制、诊断和治疗新进展，以期提高ACR的诊治效率，延长受者生存期。 |
| 关 键 词： | 肺移植 急性细胞介导排斥反应 细胞毒T淋巴细胞 人类白细胞抗原(HLA) 主要组织相容性复合体(MHC) 组织病理学检查 支气管肺泡灌洗液 血管内皮生长因子(VEGF) |
| 收稿时间： | 2021-07-06 |
New progress on diagnosis and treatment of acute cellular rejection after lung transplantation |
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| Xu Yu, Lian Qiaoyan, Chen Ao, et al. New progress on diagnosis and treatment of acute cellular rejection after lung transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(5): 614-618. doi: 10.3969/j.issn.1674-7445.2021.05.017 | |
| Authors: | Xu Yu Lian Qiaoyan Chen Ao Zhang Jianheng Xu Xin Wei Bing Cai Yuhang Huang Danxia Kuang Minting He Jianxing Ju Chunrong |
| Affiliation: | Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510012, China |
| Abstract: | Acute cellular rejection (ACR) is a common complication after lung transplantation, which is mainly caused by the immune response of T lymphocytes recognizing the major histocompatibility complex on the cellular surface of grafts. It is currently considered as the main pattern of acute rejection. ACR is not only a direct cause of death of recipients, but also a high-risk factor for chronic rejection after lung transplantation. Nevertheless, it is a challenging task to deliver the diagnosis and treatment of ACR following lung transplantation. In this article, new progresses on the risk factors, pathogenesis, diagnosis and treatment of ACR in lung transplant recipients were summarized, aiming to improve the diagnostic and treatment efficiency of ACR and prolong the survival of recipients. |
| Keywords: | Lung transplantation Acute cellular rejection Cytotoxic T lymphocyte Human leukocyte antigen (HLA) Major histocompatibility complex (MHC) Histopathological examination Bronchoalveolar lavage fluid Vascular endothelial growth factor (VEGF) |
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