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Aggressive prolactinomas responsive to temozolomide treatment: Report of two cases |
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| Authors: | Zahra Davoudi Mohammad Hallajnejad Elena Jamali Mohammadjavad Honarvar |
| Affiliation: | 1. Department of Endocrinology, Skull Base Research Center of Shahid Beheshti University of Medical Sciences, Tehran Iran ; 2. Department of Neurosurgery, Skull Base Research Center of Shahid Beheshti University of Medical Sciences, Tehran Iran ; 3. Department of Pathology, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran Iran ; 4. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran Iran |
| Abstract: | Refractory aggressive prolactinomas are detected after the unresponsiveness to conventional therapies. We report two cases that underwent temozolomide treatment and have been in near‐complete remission ever since. We suggest the pathology techniques for earlier detection and, subsequently, treatment with temozolomide to reduce morbidities and better respond to therapy. |
| Keywords: | aggressive prolactinoma case report pituitary neoplasms prolactinoma temozolomide |