| 大鼠正畸牙移动过程中牙周组织内转化生长因子β1的变化 |
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| 引用本文： | 汪玲丽,朱虹.大鼠正畸牙移动过程中牙周组织内转化生长因子β1的变化[J].中华口腔医学杂志,1999,34(4):242-244. |
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| 作者姓名： | 汪玲丽 朱虹 |
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| 作者单位： | 白求恩医科大学口腔医学院 |
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| 摘 要： | 目的 了解大鼠正畸牙移动过程中转化生长因子β１（ｔｒａｎｓｆｏｒｍｉｎｇ ｇｒｏｗｔｈ ｆａｃｔｏｒβ１，ＴＧＦ－β１）在牙周组织内的变化，探讨ＴＧＦ－β１在正畸牙移动过程中的作用。方法 对大习正畸牙移动不同阶段的牙及牙周组织联合切片，进行免疫组织化学研究。结果 正畸牙移动过程中，牙周膜内ＴＧＦ－β１表达增加。强力第５～１０天，张力区ＴＧＦ－β１表达增加的幅度明显大于压力区。结论 ＴＧＦ－β１在正
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| 关 键 词： | 免疫组织化学 牙移动 TGF－β1 正畸牙 |
The changes of transforming growth factor beta 1 in periodontal tissue during orthodontic tooth movement |
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| WANG Lingli,ZHU Hong,LIANG Tang. School of Stomatology,Bethune University of Medical Science,Changchun.The changes of transforming growth factor beta 1 in periodontal tissue during orthodontic tooth movement[J].Chinese Journal of Stomatology,1999,34(4):242-244. |
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| Authors: | WANG Lingli ZHU Hong LIANG Tang School of Stomatology Bethune University of Medical Science Changchun |
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| Institution: | School of Stomatology, Bethune University of Medical Science, Changchun 130041. |
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| Abstract: | OBJECTIVE: To observe the distribution and change of transforming growth factor beta 1 (TGF-beta 1) in periodontal tissue and understand the role of TGF-beta 1 in orthodontic tooth movement. METHODS: Apply force on right maxillary first molars in rats, and examine the decalcified alveolodental connected tissue in different stage of tooth movement with immunohistochemical staining technique (SP method). RESULTS: TGF-beta 1 exists in normal periodontal tissue. The expression of it in periodontium increases during orthodontic tooth movement. Especially from 5 to 10 days after force application, the expression at tension side is much more than those at pressure side. CONCLUSION: TGF-beta 1 plays an important role in remodeling of periodontal tissue during orthodontic tooth movement, and can powerfully promote bone formation. |
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| Keywords: | Transforming growth factor beta 1 Immunohistochemistry Tooth movement minor |
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