高血压左室肥厚的机制研究进展（英文）

原发性高血压的左室肥厚（LVH）包括心肌细胞肥大、心肌间质细胞增生、细胞外基质堆积。血流动力学即外周阻力和容量负荷,在 LVH 发病中起了一定作用。但最近临床试验证实,一些高血压患者尽管血压得到满意控制,但左室重量仍在增加,因此,血流动力学并不是 LVH 的主要致病因素。目前认为,循环与组织局部的神经内分泌因素在致 LVH 中起了更主要的作用,一氧化氮、内皮素、肾素-血管紧张素系统、氧化应激和炎性反应、钙超载,这些神经内分泌因素除了影响压力及容量负荷外,更主要的是其本身参与了心肌肥厚的形成过程。本综述旨在为高血压新的治疗方案提供理论与实践依据。

Recent advances of the mechanism of left ventricular hypertrophy complicated by hypertension

Left ventricular hypertrophy（LVH） induced by hypertension is a powerful predictor of cardiovascular morbidity and mortality.Reversal of LVH represents a major goal in the treatment of hypertensive patients.Besides,controlling blood pressure（Bp） itself,non-hemodynamic factors play a much more important role in the progression of LVH,which include the renin-angiotensin-aldosterone and the adrenergic systems or other growth factors,such as nitric oxide and endothelin,inflammation and oxidative stress,calcium overload and so on.This review will offer theoretical and practical basis for laying down a new antihypertension therapy strategy in the future.