葡萄糖耐量试验判断肝切除量及其与肝癌术后肝功能不全的关系

目的 探讨OGTT试验在原发性肝癌(PHC)患者手术前评估肝储备功能、手术切除范围及术后并发症的价值.方法 根据术中手术切除范围,将128例PHC手术切除的患者分为3类:切除肝段数1个肝段以内包括1个者为A类;切除肝段数大于1个但在2个肝段以内且包括2个者为B类;切除肝段数大于2个者为C类.术前做OGTY及常规肝功能检查及Child-Pugh评分.记录术后腹水、黄疸发生情况.结果 Child B级的患者OGTT 60、120 min(11.23 mmol/L±2.78 mmol/L,11.79 mmol/L±3.48 mmol/L)明显高于Child A级的患者(8.56 mmol/L±2.36 mmoL/L,6.78 mmol/L±1.60 mmol/L,P<0.01),而空腹及30 min未见明显差别;Child B级中符合糖尿病诊断的发生率28.30%亦明显高于Child A(13.33%,P=0.035).A类和B类中OGTT曲线为L型者术后产生腹水率高于P和I型(P<0.05),C类中I和L型均发生腹水,且128例患者发生黄疸者OGTT曲线均为L型.OGTT曲线为P型时,A、B、C三类患者术后腹水产生率无明显差异,但曲线为I、L型时,随着肝段切除的增多,腹水产生率增多(P<0.05).结论 OGTY可作为PHC评估手术切除肝脏范围、预测术后并发症的良好指标,联合Child-Pugh分级能够较准确地评估术前肝储备功能.

Hepatic resection volume in hepatocellular carcinoma by oral glucose tolerance test and it's relationship with postoperative liver failure

Objective This prospective study was performed to evaluate the role of oral glucose toler-ance test(OGTF) in evaluating the preoperative status and postoperative complications of patients with hepa-tocellular carcinoma. Methods One hundred and twenty-eight patients with primary hepatic carcinoma (PHC) were divided into 3 groups according to the resection, in which the resection of no more than 1 seg-ment called group A, the resection of 1-2 segments called group B, the resection of more than 2 segments called group C. OGTT, routine liver function tests and Child-Pugh classification were performed in these pa-tients preoperatively. The postoperative complications were also recorded. Results Blood glucose lever of 60 min and 120 min after glucose loading test in Child B (11.23 mmol/L ± 2. 78 mmol/L, 11.79 mmol/L± 3.48 mmol/L) were significantly higher than that in Child A (8.56 mmol/L±2. 36 mmol/L, 6. 78 mmol/L ±1.60 mmol/L,P <0.01) ,but the blood glucose lever of 0 min and 30 min showed no difference. The rate of diagonis of DM in Child B was 28. 30% ,which was higher than Child A(13.33% ,P =0. 035). The OG-TT results for the L-shaped curve showed that postoperative complications were significantly higher than that of type I and P in group A and B. I-shaped and L-shaped were found ascites in group C. The cases with jaun-dice all showed L-shaped curve. When the patients' OGTT curve was P -shaped, the ascites production rate was no significantly different in these three groups. With the increase of the removal in liver, ascites produc-tion rate increased evidently in I-type and L-type(P < 0. 05). Conclusions OGTT is worthwhile to assess hepatic function reserve and postoperative complications for patients with PHC. Combination of OGTT and Child-Pugh classification has higher predictive value on hepatic function reserve.