番禺地区2011-2012年金黄色葡萄球菌的耐药性变化

目的：了解番禺地区2011-2012年间金黄色葡萄球菌的耐药性变化。方法：收集广州市番禺区中心医院2011-2012年从各类临床标本中分离出的金黄色葡萄球菌，用VITEK2 Compact及配套的鉴定卡GP与药敏卡AST-GP67进行检测，并用WHONET对其药敏结果进行统计分析。结果：2011年检出金黄色葡萄球菌623株，MRSA占342株（54.9%）；2012年检出679株，MRSA占309株（45.5%），其中青霉素G、红霉素、苯唑西林2011年的耐药率分别是94.1%、62.5%、54.9%，2012年的耐药率分别是91.6%、54.5%、45.5%。未见对万古霉素、利奈唑胺、替加环素耐药的金黄色葡萄球菌。结论：了解和掌握本院金黄色葡萄球菌的分布和流行病学规律以及耐药变化状况，对指导临床合理选用抗菌药物，延缓细菌耐药株产生具有重要意义。

The Change of Antibiotic Resistance of Staphylococcus Aureus in Panyu District Between 2011-2012

Objective：To know antibiotic resistance of Staphylococcus aureus in Pan Yu district between 2011 and 2012.Method：Various types of Staphylococcus aureus isolated from clinical specimens in Panyu district central hospital between 2011-2012 were collected,they were detected by VITEK2 Compact,GP and drug sensitive card AST-GP67,and the drug sensitivity results were analyzed by WHONET.Result：623 strains of Staphylococcus aureus was isolated in 2011,MRSA accounted for 342（54.9%）;and 679 strains of Staphylococcus aureus was isolated in 2012,MRSA accounted for 309（45.5%）,penicillin,oxacillin,erythromycin resistance rate was 94.1%,62.5%,54.9% respectively in 2011,and 91.6%, 54.5%,45.5%in 2012 respectively.No Vancomycin,linezolid and tigecycline resistant Staphylococcus aureus.Conclusion：It is important significance to understand and master the distribution and epidemiology of this hospital Staphylococcus aureus and resistance changes,to guide the clinical rational use of antimicrobial drugs,delay the bacteria resistant strains.