增生性瘢痕和瘢痕疙瘩裸鼠模型的研制

目的：复制瘢痕动物模型，旨在从形态学和组织学上验证该模型的可靠性，为瘢痕的基础研究开辟一条新途径。方法：将增生性瘢痕和瘢痕疙瘩小组织块分别植入裸鼠皮下，携带一段时间（５～１２０天），且与原瘢痕作光镜和电镜对照。结果：术后裸鼠全部成活。植入物无变性坏死，且无异性细胞浸润，并保持其原有的胶原形态，透射电镜也证实细胞特性保持不变。结论：增生性瘢痕和瘢痕疙瘩植入裸鼠体内能保持其原有的组织学结构特征，裸鼠用作瘢痕动物模型是可行的、可靠的。

Duplication of the animal model of nude mice with hypertrophic scars and keloids

Object:The model duplication of the animal with scar is to identify the feasibility and reliability of the model in the morphology and the histology and provides a new approach to the basic study of scars.Method: Pieces of hypertrophic scars and keliods were implanted into subcutaneous tissue of the nude mice. The mice carried them for a period of 5 to 120 days.And at the same time, these specimens were compared with the original ones under the light microscope and electron microscope.Results: All mice survived after the surgery .No cell degeneration,necrosis or inflammatory cell infiltration were found under the light microscope in all implants.The collagen pattern of all hypertrophic scars and keloids were remained in every cases.Histologic analysis,confirmed by transmission electron microscope,demonstrates a sustained cellular character.Conclusion: This procedure showed that the viability and morphology of hypertrophic scars and keloids are sustained when they are implanted in nude mice. It is feasible and reliable to use nude mice as the model of the animal with hypertrophic scars and keloids.