传染性非典型肺炎流行因素的病例对照研究

目的:了解传染性非典型肺炎(SARS)主要传播因素及危险因素.方法:应用1:1配比的病例对照研究方法对SARS病例与正常对照进行研究.采用条件Logistic回归分析方法进行资料分析.结果:单因素分析结果表明X1(发病前20 d内没有到外市(县)旅行史)、X2(发病前20 d内没有到过医院)、X19(发病前没有患其它疾病)对SARS的发病具有保护作用,其OR值分别为0.49(0.24～0.96)、0.44(0.27～0.71)、0.39(0.23～0.68).而X10(发病前患有高血压病)和X5(发病前20 d内与确诊(或疑似)非典病例接触)具有较强的危险性,它们的OR值分别为3.67(1.02～13.14)、11.20(3.36～37.35).而多因素分析中,只有X1、X5、X7(住宅类型)3个因素进入模型,其OR值分别为0.32(0.12～0.87)、22.93(2.54～207.02)、1.93(0.75～4.95).结论:SARS的发病与接触史、居住在居民楼、外出旅行史有关.高血压病人是高危人群,应加强防护.

CASE-CONTROL STUDY ON EPIDEMIC FACTORS OF SEVERE ACUTE RESPIRATORY SYNDROME

Objective:To understand transmission factors a nd risk factors of SA RS.Methods:Pair matching case-control study with 180 cases of SARS and 180 contr ols was univariate analysis.Results:X1(not travel to any ot her areas in recent 20 days) ,X2(not went to hospital in recent 20 days),X19(no other diseases),had negative associations with SARS,and their ORs were 0.49(0.24-0.96),0.44(0.27-0.71 ),0.39 (0.23-0.68) respectively.X10(hypertension),X5(contacting with SARS ca ses)had sign ificantly positive associations,and their ORs were 3.67(1.02-13.14) and 11.2 0(3.36 -37.35).The result of multivariate logistic analysis showed that X1,X5,X7 (typ e of residense) were related to SARS,and their ORs were 0.32(0.12-0.87),22. 93(2.54-207.02 ) and 1.93(0.75-4.95) respectively.Conclusion:Our data sho wed that contacting with SARS case, living in dormitory and apartment,travel were associated with SARS .It suggedte d that keeping patients isolation, not traveling during the time of epidemic of S ARS , and ventilating the room may reduce the incidence rate of SARS,and suffer ing from hypertension was risk factor.