| 对比剂剂量及注射流率对去卷积法兔肝脏CT灌注值的影响 |
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| 引用本文： | 肖景坤,刘斌,王万勤,方雷,吴兴旺,余永强.对比剂剂量及注射流率对去卷积法兔肝脏CT灌注值的影响[J].中国医学影像技术,2010,26(4):612-615. |
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| 作者姓名： | 肖景坤 刘斌 王万勤 方雷 吴兴旺 余永强 |
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| 作者单位： | 1. 安徽医科大学第一附属医院放射科,安徽,合肥,230022;安徽省立医院影像科,安徽,合肥,230002
2. 安徽医科大学第一附属医院放射科,安徽,合肥,230022 |
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| 摘 要： | 目的 探讨去卷积法肝脏CT灌注成像时对比剂剂量和注射流率对灌注参数值的影响.方法 对8只实验兔采用配伍组设计:处理因素为注射流率,分别为0.5 ml/s、1.0 ml/s、1.5 ml/s;配伍因素为对比剂剂量,分别为0.5 ml/kg、1.0 ml/kg、1.5 ml/kg.将灌注扫描数据传入工作站,利用Perfusion 3中的肝脏灌注软件进行分析,计算各灌注值.结果 对比剂剂量对主动脉、门静脉和肝实质增强峰值有显著性影响(P<0.05);对比剂注射流率对主动脉、门静脉的增强峰值时间有显著性影响(P<0.05);注射流率和剂量对肝血流量(HBF)、肝动脉指数(HAF)、肝血容量(HBV)、毛细血管平均通过时间(MTT)和表面通透性(PS)均无显著性影响(P>0.05).结论 去卷积法肝脏CT灌注成像可以定量研究肝脏微循环血流动力学状态,结果稳定,对对比剂剂量和注射流率要求相对不高,有较好的临床实用价值.
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| 关 键 词： | 肝脏 体层摄影术 X线计算机 灌注成像 对比剂 |
| 收稿时间： | 2009/9/23 0:00:00 |
| 修稿时间： | 2009/11/6 0:00:00 |
Influence of various doses and injection rates of contrast agent on CT perfusion in rabbits' liver with deconvolution method |
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| XIAO Jing-kun,LIU Bin,WANG Wan-qin,FANG Lei,WU Xing-wang and YU Yong-qiang.Influence of various doses and injection rates of contrast agent on CT perfusion in rabbits' liver with deconvolution method[J].Chinese Journal of Medical Imaging Technology,2010,26(4):612-615. |
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| Authors: | XIAO Jing-kun LIU Bin WANG Wan-qin FANG Lei WU Xing-wang and YU Yong-qiang |
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| Institution: | Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Medical Imaging, Anhui Provincial Hospital, Hefei 230002, China;Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China |
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| Abstract: | Objective To study the influence of various doses and injection rates of contrast agent on CT perfusion in rabbits' liver with a deconvolution mathematical model. Methods Eight rabbits were enrolled in the experiment. Randomized block design was adopted. The treatment factor (contrast medium injection rate) was classified into 0.5,1.0,1.5 ml/s,while the subjects were divided into 3 blocks with contrast medium injection dose of 0.5,1.0 and 1.5 ml/kg. The data obtained at CT perfusion imaging were then transf... |
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| Keywords: | Liver Tomography X-ray computed Perfusion imaging Contrast media |
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