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| 慢性高原病患者骨髓组织Survivin 及VEGF表达水平和MVD变化 | |
| 引用本文： | 袁霞,李占全,柴克霞,冀林华,冶俊玲,郭新建. 慢性高原病患者骨髓组织Survivin 及VEGF表达水平和MVD变化[J]. 青海医学院学报, 2009, 30(3) |
| 作者姓名： | 袁霞 李占全 柴克霞 冀林华 冶俊玲 郭新建 |
| 作者单位： | 1. 青海大学附属医院血液科 2. 青海大学附属医院病理科 |
| 摘 要： | 目的 了解Survivin及VEGF在慢性高原病(CMS)骨髓组织中的表达和MVD的变化,探讨细胞凋亡与血管新生在CMS发生、发展中的作用.方法 应用免疫组织化学SP法检测20例CMS患者(CMS组)及15例长期居住西宁地区健康人(对照组)骨髓组织中Survivin及VEGF的表达情况和MVD的变化(用CD34单抗标记的血管计数法)并进行比较分析.结果 CMS组Survivin及VEGF阳性表达率分别为70%、75%,均显著高于对照组(分别为26.67%及33.33%,P值均＜0.05);CMS组MVD为31.93±6.13,也明显高于对照组(24.94±6.18),P＜0.01.CMS组Survivin阳性表达率、VEGF阳性表达率、MVD及Hb相互间均呈显著正相关(均为P＜0.01).结论 CMS骨髓组织中Survivin和VEGF表达升高, MVD增加,提示Survivin可能通过抑制细胞凋亡,与VEGF协同促进血管生成和红细胞增殖,参与CMS的发生发展. |
| 关 键 词： | 凋亡抑制蛋白 血管内皮生长因子 微血管密度 |
THE STUDY ON THE EXPERSSIONS OF SURVIVIN VEGF AND THE MVD IN BONE MARROW OF PATIENTS WITH CHRONIC MOUNTAIN SICKNESS |
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| Yuan Xia,Li Zhanquan,Chai Kexia,Ji Linhua,Ye JunLin,Guo XinJian. THE STUDY ON THE EXPERSSIONS OF SURVIVIN VEGF AND THE MVD IN BONE MARROW OF PATIENTS WITH CHRONIC MOUNTAIN SICKNESS[J]. Journal of Qinghai Medical College, 2009, 30(3) | |
| Authors: | Yuan Xia Li Zhanquan Chai Kexia Ji Linhua Ye JunLin Guo XinJian |
| Affiliation: | Yuan Xia1,Li Zhanquan1,Chai Kexia1,Ji Linhua1,Ye JunLin2,Guo XinJian2 (1.Department of Hematology,Qinghai University Affiliated Hospital,2.Department of Pathology,Qinghai University Affiliated Hospital) |
| Abstract: | Objective To explore the pathological roles of apoptosis and angiogenesis in the progenesis and progress of chronic mountain sickness(CMS) by evaluating the expressions of survivin and VEGF and the change of microvessel density(MVD) in bone marrow of patients with CMS.Methods The samples of bone marrow used in this study were obtained from 20 patients with CMS(CMS group) and 15 healthy adults(control group).The expressions of survivin and VEGF in bone marrows were detected using the SP immunohistochemistry ... |
| Keywords: | Survivin Vascular endothelial growth factor Microvessel density |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |