Drug hypersensitivity syndrome induced by sulfasalazine: A case report

Introduction:Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality.Patient concerns:A 52-year-old man was hospitalized for developing a rash after 3 weeks of sulfasalazine treatment for ulcerative colitis (UC).Diagnosis:The patient was diagnosed with DHS based on his drug history, clinical manifestations, and laboratory test results.Interventions:The patient was administered intravenous glucocorticoids. The patient’s condition improved after treatment with human immunoglobulin and antihistamines.Outcomes:Combination therapy of glucocorticoid and gamma globulin, the whole-body pruritus disappeared, and no new rash appeared. The whole-body rash subsided or turned dark red.Conclusion:This article describes the diagnosis and treatment process of a case of sulfasalazine-induced DHS and reviews the relevant literature to improve clinician understanding and avoid misdiagnosis and missed diagnosis.