男性代谢综合征对青春期子代影响的家族聚集性分析

目的 分析男性代谢综合征(MS)患者青春期子代和健康人青春期子代的MS各组分及血清超敏C反应蛋白(hs-CRP)等疾病表型的差异,探讨MS及其相关组分的家族聚集特征.方法 采用遗传流行病学1:3病例对照家系设计,确定26例男性MS作为先证者(病例组)以及78名健康人作为对照组.通过体格检查和实验室检查收集两组研究对象青春期子代的疾病表型信息.测定身高、体重、腰围、臀围、血压,计算BMI、腰臀比和腰围身高比.实验室检测空腹血糖、血脂四项及血清hs-CRP含量.结果 MS病例组青春期子代的肥胖指标(腰围、腰围身高比、腰臀比、DBP值)及hs-CRP值均高于对照组的青春期子代(P＜0.05).病例组青春期子代的MS、中心性肥胖率以及血脂异常率(低HDL-C)均高于对照组子代(P＜0.05).并且病例组子代患MS组分数量显著高于对照组(r=0.231,P＜0.05).结论 病例与对照组青春期子代的疾病表型存在差异;提示MS的家族聚集性在青春期即已体现,主要表现在中心性肥胖、血压升高和炎症表达明显.

Familial aggregation of metabolic syndrome in adolescents with paternal metabolic syndrome

Objective To analyze the impact of parental Metabolic Syndrome(MS)on adolescents,and to explore the familial aggregation of MS with its components.Methods Using a 1:3 case-control familial study design to choose 26 MS male patients as proband and 78 healthy men as controls.Data regarding phenotype of their adolescence offspring were collected.Height,weight,waist circumference(WC),blood pressure,body mass index(BMI),waist-to-hip ratio(WHR)and waist-to-height ratio(WHtR)were measured or calculated.FPG,TC,TG,HDL-C and LDL-C were detected by automatic biochemical analyzer and hs-CRP was detected.Results WC,WHtR,WHR,DBP and hs-CRP of those adolescents with paternal MS were significantly higher than in controls(P＜0.05).Rates of MS,Obesity depend WC,low level of HDL-C of adolescent with paternal MS were significantly higher than in controls(P＜0.05).The rate of number on MS was significantly higher in case group than in control(r=0.231,P＜0.05).Conclusion The phenotypes of MS were different between adolescents with or without parental MS,indicating that the familial aggregation of MS had been existed in their adolescent offspring,and mainly presented in central obesity,increased blood pressure and inflammation.