The association between long-term platelet count and disability-free survival among middle-aged and older Chinese: Evidence from the China Health and Retirement Longitudinal Study |
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| Institution: | 1. Department of Acute Infectious Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, 214023, China;2. Department of Acute Infectious Disease Control and Immunization Program, Wuzhong Center for Disease Control and Prevention, Suzhou, Jiangsu, 215000, China;3. Department of Health Promotion and Chronic Non-Communicable Disease Control, Wuzhong Center for Disease Control and Prevention, Suzhou, Jiangsu, 215000, China;4. The First Affiliated Hospital of Kangda College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People''s Hospital of Lianyungang, Lianyungang, Jiangsu, 222000, China;5. Department of Chronic Non-Communicable Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, 214023, China;6. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, 215000, China;7. Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine Jiangnan University, Wuxi, Jiangsu, 214122, China;1. Department of Food and Nutrition, Chung-Ang University, Gyeonggi-do 17546, Republic of Korea;2. Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia;1. Department of Nephrology, Jiangmen Central Hospital, Jiangmen, China;2. Department of Medical Statistics, Clinical Trials Unit, The First Affiliated Hospital, Sun Yat-sen Univeristy, Guangzhou, China;3. Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, China;4. Department of Nephrology, Zhujiang Hospital, Southern Medical University Guangzhou, China;5. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou Univeristy, ZhengZhou, China;6. Department of Nephrology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;7. Department of Nephrology, Jiujiang NO.1 People''s Hospital, Jiujiang, China;8. Department of Hematology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China;9. Department of Nephrology, DongGuan SongShan Lake Tungwah Hospital, DongGuan, China;10. Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, China;11. Department of Nephrology, Affiliated Sixth People''s Hospital, Shanghai Jiao Tong Univeristy, Shanghai, China;1. Department of Clinical Medicine and Surgery, “Federico II” University, Naples, Italy;2. Division Impacts on Agriculture, Forests and Ecosystem Services (IAFES), Foundation Euro- Mediterranean Center on Climate Change (CMCC), Viterbo, Italy;1. Department of Medicine, Division of Endocrinology and Metabolism, Western University, 268 Grosvenor Street, N6A 4V2, London, Ontario, Canada;2. Department of Epidemiology and Biostatistics, Western University, 1465 Richmond Street, N6G 2M1, London, Ontario, Canada;3. Centre for Diabetes, Endocrinology and Metabolism, St. Joseph''s Health Care London, 268 Grosvenor Street, N6A 4V2, London, Ontario, Canada;4. ICES Western, 800 Commissioners Road East, N6A 5W9, London, Ontario, Canada;5. Lawson Health Research Institute, 750 Base Line Road East, Suite 300, N6C 2R5, London, Ontario, Canada;6. Department of Medicine, Western University, 800 Commissioners Road East, N6A 5W9, London, Ontario, Canada;7. Department of Family Medicine, Western University, 1465 Richmond Street, N6G 2M1, London, Ontario, Canada;8. Department of Medicine, Division of Gastroenterology, Western University, 800 Commissioners Road East, N6A 5W9, London, Ontario, Canada;9. Department of Medicine, Division of Nephrology, Western University, 800 Commissioners Road East, N6A 5W9, London, Ontario, Canada;10. Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street, N6A 5C1, London, Ontario, Canada;1. Human Nutrition & Exercise Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK;2. Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia;3. School of Life Sciences, The University of Nottingham, Nottingham, UK;4. School of Population Health, Curtin University, Perth, Australia;1. Department of Pharmacotherapy, College of Pharmacy. University of Utah, Salt Lake City, UT, USA;2. Department of Pharmacy Practice, College of Pharmacy. Mercer University, Atlanta, GA, USA |
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| Abstract: | Background and aimsWe aimed to assess the associations of baseline and long-term platelet count (PLT) with disability-free survival (DFS) among middle-aged and older Chinese.Methods and resultsA total of 7296 participants were recruited in the analysis. Updated mean PLT was defined as the mean of the two PLT measurements (4 years between wave 1–3). The long-term status of PLT was defined as persistent low, attenuated, increased and persistent high PLT according to the optimal cut points from the receiver operating characteristic curves of the two PLT measurements, respectively. The primary outcome was DFS, evaluated by the first occurrence of either disability or mortality. During 6-year visit, 1579 participants experienced disability or all-cause mortality. The rates of primary outcome were significantly higher among participants with elevated baseline PLT and updated mean PLT. Multivariable adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of primary outcome were 1.253 (1.049–1.496) for highest baseline PLT tertile and 1.532 (1.124–2.088) for highest updated mean PLT tertile, comparing to the lowest tertiles. Multivariable-adjusted spline regression models showed a linear association of baseline PLT (plinearity < 0.001) and updated mean PLT (plinearity = 0.005) with primary outcome. Moreover, participants with persistent high PLT and increased PLT had increased risk of primary outcome (ORs 95% CIs]: 1.825 1.282–2.597] and 1.767 1.046–2.985], respectively), compared with the reference of those with persistent low PLT.ConclusionThis study proved elevated baseline PLT, especially long-term persist high or increased PLT was associated with less likelihood of DFS among middle-aged and older Chinese. |
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| Keywords: | Platelet count Long-term status Disability-free survival Dose–response association Predictive value |
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