Family history,waist circumference and risk of ischemic stroke: A prospective cohort study among Chinese adults |
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| Institution: | 1. Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266071, China;2. Qingdao Municipal Center for Disease Control and Prevention, Qingdao Institute of Preventive Medicine, Qingdao 266033, China;3. Department of Vascular Surgery, Qingdao Municipal Hospital, Qingdao 266071, China;4. National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences, Beijing 100037, China;5. Chinese Academy of Medical Sciences, Beijing 102308, China;6. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, Medical Research Council Population Health Research Unit, University of Oxford, Oxford OX3 7LF, United Kingdom;7. Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, China;8. Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China;1. Department of Internal Medicine, “S. Maria delle Grazie”, Pozzuoli Hospital, Naples, Italy;2. Department of Movement Sciences and Wellbeing, University of Naples Parthenope, Naples, Italy;3. Obesity and Endocrine Disease Unit, Department of Neuroscience, AORN Santobono-Pausilipon Children''s Hospital, Naples, Italy;4. Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy;5. IRCCS Bambino Gesù Children''s Hospital, Rome, Italy;6. Institute of Translational Pharmacology, National Research Council, Rome, Italy;7. Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy;8. Department of Cardiology, “S. Maria delle Grazie”, Pozzuoli Hospital, Naples, Italy;9. Hypertension Research Centre & Department of Advanced Biomedical Sciences, Federico II University Hospital, Naples, Italy;1. Federal University of Santa Catarina (UFSC), Postgraduate Program in Nutrition, Brazil;2. School of Public Health, University of São Paulo (USP), Postgraduate Program in Nutrition in Public Health, Brazil;3. Federal University of Paraná (UFPR), Departamento de Nutrição, Brazil;4. Federal University of Rio de Janeiro (UFRJ), Institute of Studies on Collective Health, Brazil;5. Federal University of Grande Dourados (UFGD), School of Health Sciences, Brazil;1. Unit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Italy;2. Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Messina, Italy;3. Cardiovascular Division, Faculty of Life Science & Medicine, King''s College London, London, UK;4. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy;1. Sports Performance Laboratory, School of Physical Education & Sports Science, National and Kapodistrian University of Athens, Greece;2. Department of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio University, Greece;3. Theseus, Physical Medicine and Rehabilitation Center, Athens, Greece;4. A’ Neurology Clinic, Aiginition Hospital, Medical School, National and Kapodistrian University of Athens, Greece;1. Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China;2. Department of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China;3. Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, Henan, China |
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| Abstract: | Background and aimsThe associations between genetic factors and waist circumference (WC) with stroke risk have been evaluated in Western studies. However, evidence of this association has rarely been reported in the Chinese population. This study aimed to evaluate the association between WC and family history of stroke (FHS) with ischemic stroke (IS) risk among Chinese adults and to further explore the potential interaction of these associations.Methods and resultsThe China Kadoorie Biobank (CKB) study recruited 35,508 participants aged 30–79 years from the Qingdao urban area during 2004–2008. A total of 33,355 participants were included in study. Cox regression analysis was used to estimate the multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the independent and interactional associations between FHS and WC and IS risk. Participants with FHS had a 29% (HR = 1.29, 95% CI: 1.12–1.50) higher IS risk than those without FHS. Participants with excessive WC (85 cm for males and 80 cm for females) had a 78% (HR = 1.78, 95% CI: 1.51–2.10) higher IS risk than those with normal WC. The combined effect of FHS and excessive WC on IS was statistically significant (HR = 2.29, 95% CI: 1.84–2.86). The present study further found statistically significant multiplicative interactions of FHS and WC with IS risk (P interaction < 0.001).ConclusionThe present study indicated that FHS and WC were significantly associated with an increased risk of IS. The association between FHS and IS was associated with excessive WC. |
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| Keywords: | China Family history Waist circumference Ischemic stroke Prospective study |
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