重视葡萄膜炎药物治疗研究,提高葡萄膜炎药物治疗效果

各类非感染性葡萄膜炎的治疗,糖皮质激素是首选药物.但单一药物治疗对慢性或复发性葡萄膜炎的疗效欠佳,长期应用又具有明显的毒副作用,因此部分患者需辅助以免疫抑制剂或生物制剂治疗.不同类型免疫抑制剂和生物制剂的作用机制不完全相同,因此各自的适应证、疗效和毒副作用也不尽一样.在临床实践中,应根据葡萄膜炎的类型选择敏感的免疫抑制剂或生物制剂治疗,同时密切观察其疗效和毒副作用.葡萄膜炎治疗中的常用药物类型、疗效以及存在的问题值得我们进一步关注和深入研究,以提高葡萄膜炎药物治疗的效果.

Drug treatment of non-infectious uveitis

The corticosteroids are the first-line therapeutical agents for non-infectious uveitis patients, but systemic corticosteroids are ineffective for some chronic or recurrent patients, and have many long term usage-related side effects; these patients may need treatment of immunosuppressive agents and/or biologic agents. However, the mechanism, indication, efficacy and side-effects of each type of the immunosuppressive agents or biologic agents are not identical. In clinical practice, we should use different and sensitive immunosuppressive agents or biologic agents for different types of uveitis, and watch their efficacy and toxic effects closely. In order to improve the effectiveness of the treatment, the classification,efficacy and existing concerns of commonly used uveitis drugs need to be further clarified.