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Inhibitory effect of intragastric glucose on gastric acid secretion and gastric emptying of liquids in man |
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| Authors: | Haruka Sasaki Murugasu Nagulesparan Andre Dubois Barbara Vasquez Eugene Straus Maurice L. Sievers Roger H. Unger |
| Affiliation: | 1. Human Diabetes Study Center, 4212 North 16 Street, 85016, Phoenix, Arizona 2. Human Diabetes Study Center, University of Texas Southwestern Medical School, Dallas, Texas 3. Phoenix Clinical Research Section, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Phoenix, Arizona 4. Phoenix Indian Medical Center, Phoenix, Arizona 5. Digestive Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 6. Department of Clinical Sciences, Albert Einstein College of Medicine at the Montefiore Hospital and Medical Center, Bronx, New York |
| Abstract: | Intragastric glucose inhibits gastric acid secretion and gastric emptying in man. To determine if these effects are mediated by somatostatin—a known inhibitor of gastric acid production, gastrin secretion, and gastric motility—the plasma somatostatin-like immunoreactivity (SLI) levels were determined in healthy human subjects after an intragastric load of 30% glucose solution. These findings were compared with results after an instillation of distilled water. Following the glucose load, the intragastric acid concentration, the acid output, and the fractional gastric emptying rate declined significantly (P<0.01) before either the plasma glucose or plasma insulin levels had increased. Neither the gastrin nor SLI plasma concentrations changed after the water or glucose load. These findings suggest that the suppression of gastric acid secretion and inhibition of the rate of gastric emptying that occur with intragastric glucose are mediated by factors other than changes in the peripheral circulating levels of SLI, gastrin, insulin, or glucose. |
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