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延迟性低温复合巴曲酶对沙土鼠全脑缺血后神经的影响
引用本文:王士雷,曾因明,陈群. 延迟性低温复合巴曲酶对沙土鼠全脑缺血后神经的影响[J]. 中华麻醉学杂志, 1999, 19(5): 294-297
作者姓名:王士雷  曾因明  陈群
作者单位:[1]青岛医学院附属医院麻醉科 [2]徐州医学院麻醉重点实验室
摘    要:
目的 研究短暂全脑缺血后30分开始的低温复合巴曲酶对沙土鼠行为学和组织病理学的影响。方法 采用沙土鼠全脑缺血模型,缺血时间10分,动物随机分为5组,假手术组,常温组,延迟性低温组,巴曲酶组,延迟性低温复合巴曲酶组,每组7只,低温(32℃)于再灌注30分给予,维持3小时,巴曲酶8BU.kg^-1再灌注30分经腹腔注入,于动物存活第5天行开阔法行为学检查,第7天行海马CA1我组织病理学检查,结果 行为

关 键 词:脑缺血 蛇毒凝血酶 人工低温 麻醉

Effects of delayed hypothermia combined with batroxobin on behavior and histopathology following global cerebral ischemia in gerbils
WANG Shilei,ZENG Yinming,CHEN Qun,et al.. Effects of delayed hypothermia combined with batroxobin on behavior and histopathology following global cerebral ischemia in gerbils[J]. Chinese Journal of Anesthesilolgy, 1999, 19(5): 294-297
Authors:WANG Shilei  ZENG Yinming  CHEN Qun  et al.
Affiliation:WANG Shilei,ZENG Yinming,CHEN Qun,et al.Jiang Su Province Key Laboratory of Anaesthesiology,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002
Abstract:
Objective The effects of delayed hypothermia combined with batroxobin on behavior and histopathology following global cerebral ischemia in gerbils were studied.Methods The ischemia was induced by occlusing the bilateral common carotoid arteries for ten minutes.Thirty five gerbils were divided into five groups:sham operated group;normothermia group;delayed hypothermia group;batroxobin group;delayed hypothermia combined with batroxobin group.Open field test were carried out at the fifth day,and histopathology test at the seventh day.Results The exploring activities of gerbils in both batroxobin and delayed hypothermia group were lower than that in normothermia reperfusion group,but higher than in hypothermia combined with batroxobin group.Animals of batroxobin group or delayed hypothermia group showed less neuron loss of CA1 than that of normothermia group,but more neuron loss of CA1 than that of hypothermia combined with batroxobin group.Conclusion Batroxobin or delayed hypothermia provides neuroprotective effects from the behavior deficits as well as neuronal injury following transient global cerebral ischemia,and their efficacy is substantially elevated when the treatments are combined.
Keywords:Cerebral ischemia Reptilase Hypothermia  induced
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