| 菘蓝的4种有效成分及配伍组合抗腺病毒作用的研究 |
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| 引用本文： | 赵玲敏,杨占秋,方建国,汤杰,丁晓华,肖红. 菘蓝的4种有效成分及配伍组合抗腺病毒作用的研究[J]. 中药新药与临床药理, 2005, 16(3): 178-181 |
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| 作者姓名： | 赵玲敏 杨占秋 方建国 汤杰 丁晓华 肖红 |
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| 作者单位： | 1. 武汉大学医学院病毒研究所,武汉,430071
2. 华中科技大学同济医学院同济医院药剂科,武汉,430030 |
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| 摘 要： | 目的从菘蓝中提取出 4种有效成分(编以代码为 6号,7号,8号,9号 ),观察 4种有效成分及其配伍抗腺病毒活性.方法通过观察细胞病变效应(CPE),噻唑兰(MTT)比色法检测细胞活性,以确定 4种有效成分及其配伍抗腺病毒的作用.结果菘蓝的 4种有效成分及其配伍组合对腺病毒生物合成都有抑制作用.随着药物浓度的增加,CPE逐渐减弱,病毒的抑制率增加.结论菘蓝的 4种有效成分及其配伍组合能在体外通过抑制生物合成发挥抗腺病毒作用.
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| 关 键 词： | 菘蓝 腺病毒 有效成分 配伍 抗病毒实验 |
| 文章编号： | 1003-9783(2005)03-0178-04 |
| 修稿时间： | 2004-11-07 |
Anti-adenovirus Action of the Four Active Components of Isatis Tinctoria L. and Their Combination |
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| ZHAO Lingmin,Yang Zhanqiu,FANG Jianguo,TANG Jie,DING Xiaohua,XIAO Hong. Anti-adenovirus Action of the Four Active Components of Isatis Tinctoria L. and Their Combination[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2005, 16(3): 178-181 |
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| Authors: | ZHAO Lingmin Yang Zhanqiu FANG Jianguo TANG Jie DING Xiaohua XIAO Hong |
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| Abstract: | Objective To investigate the in -vitro anti -ad enovirus activity of the four active components of Isatis tinc-toria L.(No.6,7,8,and 9)and their combination.Methods Anti -adenovirus effects were investigated by observing the cytopathic effect(CPE)and detecting the cellular activity with MTT colorimetric assay.Results The four active com-ponents and their combination had in hibitory effect on the biological sy nthesis;with the increase of the drug concent ra-tion,the CPE effect decreased and in hibitory rate for virus increased.Conclusion The four active components and their combination have anti -adenovirus a ctivity by inhibiting the biological synthesis in vitro. |
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| Keywords: | Isatis tinctoria L. Adenovirus Active components Compatibility Antiviral test |
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