| 内皮细胞微粒与糖尿病心肌病 |
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| 引用本文： | 姚轻舟,雷和平. 内皮细胞微粒与糖尿病心肌病[J]. 国际病理科学与临床杂志, 2012, 32(2): 130-134. DOI: 10.3969/j.issn.1673-7347.2012.02.008 |
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| 作者姓名： | 姚轻舟 雷和平 |
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| 作者单位： | 1.广东省人民医院医学研究中心、广东省医学科学院,广州510080;南方医科大学药学院,广州510080;2.广东省人民医院医学研究中心、广东省医学科学院,广州,510080 |
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| 基金项目： | 国家自然科学基金,中国博士后科学基金 |
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| 摘 要： | 内皮细胞激活、损伤、凋亡时,会向细胞外释放内皮微粒,其作为反映内皮细胞功能的新型标记物,在多种病理状态时都有增加.糖尿病心肌病的病理过程中,内皮损伤、血管再生、氧化应激与炎症反应以及肾素血管紧张素系统激活等过程都与内皮微粒存在紧密联系.
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| 关 键 词： | 内皮微粒 糖尿病心肌病 肾素血管紧张素系统 炎症反应 |
Endothelial microparticles and diabetic cardiomyopathy |
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| YAO Qingzhou , LEI Heping. Endothelial microparticles and diabetic cardiomyopathy[J]. Journal of International Pathology and Clinical Medicine, 2012, 32(2): 130-134. DOI: 10.3969/j.issn.1673-7347.2012.02.008 |
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| Authors: | YAO Qingzhou LEI Heping |
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| Affiliation: | 1 (1.Medical Research Center of Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080; 2.Pharmaceutical School,Southern Medical University,Guangzhou 510080,China) |
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| Abstract: | Endothelial microparticles(EMPs) are small membrane vesicles that shed from the surface of endothelial cells in response to activation or apoptosis.As a new marker of endothelial cell function,increased levels of EMP have been documented in several diseases.The pathogenesis of diabetic cardiomyopathy was associated with persistence of endothelial dysfunction,angiogenesis,oxidative stress,and inflammation.The activation of the renin-angiotensin system also involves EMPs. |
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| Keywords: | endothelial microparticles diabetic cardiomyopathy renin-angiotensin system imflammation |
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