| 脂肪细胞脂肪酸结合蛋白与妊娠及其并发症 |
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| 引用本文： | 王晓娟（综述）,颜建英（审校）. 脂肪细胞脂肪酸结合蛋白与妊娠及其并发症[J]. 国外医学:妇产科学分册, 2010, 37(3): 168-170,197 |
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| 作者姓名： | 王晓娟（综述） 颜建英（审校） |
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| 作者单位： | [1]福建医科大学研究生学院,福州350004 [2]福建医科大学教学医院 福建省妇幼保健院妇产科,福州350004 |
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| 摘 要： | 脂肪细胞脂肪酸结合蛋白（FABP4）是脂肪酸结合蛋白家族的成员，与饱和／不饱和长链脂肪酸、类花生四烯酸和其他脂质有高度亲和力，参与脂肪酸的吸收、转运和代谢，在糖脂代谢、炎症反应中起重要作用。新近研究发现，FABP4在代谢综合征、心血管疾病、糖尿病等疾病中发挥重要作用，并与妊娠相关疾病，如子痫前期、妊娠期糖尿病发病相关。明确其作用机制及影响因素，可为相关疾病预防和治疗提供新思路。
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| 关 键 词： | 脂肪细胞脂肪酸结合蛋白 子痫前期 妊娠期糖尿病 |
Relationship Between Adipocyte Fatty Acid-binding Protein and Pregnancy-associated Diseases |
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| Fujian Medical University,Fuzhou ,China. Relationship Between Adipocyte Fatty Acid-binding Protein and Pregnancy-associated Diseases[J]. Foreign Medical Sciences(Obstet Gynecol Fascicle), 2010, 37(3): 168-170,197 |
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| Authors: | Fujian Medical University Fuzhou China |
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| Affiliation: | Fujian Medical University,Fuzhou 350004,China(WANG Xiao-juan),Department of Obstetricsand Gynecology,The Teaching Hospital Fujian Maternity and Children Health Hospital,Fuzhou 350001,China(YAN Jian-ying) |
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| Abstract: | Adipocyte fatty acid-binding protein(FABP4/AFABP/aP2)is a member of the fatty acid-binding protein family that bind with high affinity to saturated and unsaturated long-chain fatty acids,eicosanoids and other lipids.Its functions include shuttling free fatty acids,regulating cellular lipid metabolism and expression of inflammatory cytokine.Recent studies have indicated that FABP4 have a central role in the development of metabolic syndrome,cardiovascular and diabetes mellitus.It is also known to contribute ... |
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| Keywords: | Adipocyte fatty acid-binding protein Preeclampsia Gestational diabetes mellitus |
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