丁香罗勒油透皮凝胶的制备及其体外透皮性能

摘要：目的 制备一种丁香罗勒油透皮凝胶，观察其体外透皮性能。方法 以具有良好生物相容性的亲水性高分子材料羧甲基纤维素钠和聚乙烯醇为辅料，制备丁香罗勒油透皮剂。采用改良Franz扩散池，以鼠背皮肤为屏障进行经皮渗透实验，气相色谱法检测丁香罗勒油（以丁香酚为指标）的经皮渗透量。结果 羧甲基纤维素钠和聚乙烯醇两种高分子骨架材料在凝胶基质中的浓度对丁香罗勒油透皮能力有较大的影响，以25%含量（聚乙烯醇与羧甲基纤维素钠总量）为最佳。结论 丁香罗勒油透皮凝胶可用作为丁香罗勒油的良好载体有望极大地提高其功效。

Preparation of Ocimum gratissimum L. oil transdermal gel and its skin penetration in vitro

Abstract: Objective To prepare an Ocimum gratissimum L. oil transdermal gel and to investigate its skin penetration in vitro. Methods: An Ocimum gratissimum L. oil transdermal gel was prepared by using hydrophilic polymer sodium carboxymethyl cellulose and polyvinyl alcohol each with good biocompatibility. In the experimental installation for skin penetration in vitro, the mouse dorsal skin was isolated as a barrier for percutaneous penetration experiments. The percutaneous infiltration quantity of Ocimum gratissimum L. oil (eugenol as the indicator) was determined by high resolution gas chromatography. Results The ratio of polyvinyl alcohol and scarboxymethyl cellulose showed no significant effect on the transdermal ability of Ocimum gratissimum L. oil. But their concentration in the gel matrix had a certain influence on the transdermal ability of Ocimum gratissimum L. oil, and 25% content (total content of sodium carboxymethyl cellulose and polyvinyl alcohol) was optimal. Conclusion These results suggested that this kind of transdermal gel could be used as a good carrier for Ocimum gratissimum L. oil.