易坦静佐治儿童下呼吸道感染疗效Meta分析

目的 根据国内2005～2011年公开发表的随机对照性研究结果,评价易坦静（氨溴特罗口服液）佐治儿童下呼吸道感染的效果.方法 检索2005～2011年国内公开发表的中文文献,关键词为易坦静或氨溴特罗、儿童.对加用易坦静或进行常规治疗的下呼吸道感染患儿,进行治疗有效率的Meta分析,评价疗效.结果共检索出的相关文献104篇,经筛选74篇文献符合本次Meta分析的纳入标准.共8 745例研究对象被纳入治疗有效率评价,各研究方差齐性检验差异无统计学意义,采用Meta分析固定效应模型,加用易坦静组与对照组的有效率OR值,合并均值及95%可信区间为3.64（3.18～4.17）.结论易坦静佐治下呼吸道感染患儿疗效显著.

Evaluation of Effects of Ambroxol Hydrochloride and Clenbuterol HydrochlorideOral Solution on Lower Respiratory Tract Infection in Children

Objective According to literatures at home published from 2005 to 2011,based on random-controlled studies,effects of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution on lower respiratory tract infection in children were evaluated. Methods Through Meta-analysis,all articles related to Ambroxol Hydrochloride and Clenbuterol Hydrochloride and Ambrocoloral liquid between 2005~2011 were studied to evaluate the effects of Ambrocol oral liquid on lower respiratory tract infection symptoms. Results 104 papers published during 2005 to 2011 were selected into this study.74 papers and 8745 cases were included into study after screen.There was no difference of homogeneity test of variance between different studies.Homogeneity test showed that fixed effect model should be selected for assessing the efficacy.The combined odds ratio means of efficacy in children with infectious pneumonia Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution with intervention were 3.64（3.18～4.17）. Conclusion Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution is effective for lower respiratory tract infection in children.