乳腺癌术后骨转移回顾性分析

目的 分析乳腺癌术后骨转移的临床特征.方法 对407例原发乳腺癌术后发生骨转移的情况进行回顾性分析.结果 50例患者术后发生骨转移.这50例患者中,术后30个月内发生骨转移的病例占54.0%,5年内骨转移发生率为76.0%,发病年龄≤50岁的占60%.病理类型以浸润性导管癌为主的占82.0%.骨转移部位最多发生在脊柱,以胸椎、腰椎为主.其次是骨盆、肋骨、胸骨、颅骨、下肢骨.乳腺癌术后是否出现骨转移在年龄、腋淋巴结转移、孕激素受体(PR)、癌基因CerbB2表达方面无统计学差异(P＞0.05).但在肿瘤病理类型及雌激素受体(ER)表达方面的差异有统计学意义(P＜0.05).结论 乳腺癌术后30个月内为骨转移高发期,骨转移部位以脊柱及骨盆、肋骨、胸骨多见.乳腺癌术后发生骨转移与年龄、腋淋巴结转移、PR、CerbB2表达方面无关,与肿瘤病理类型、ER有关.

A retrospective analysis of cases of bone metastases in patients operated for breast cancer

Objective To analyze the clinical symptoms of bone metastases after breast cancer operation. Methods Retrospectively analyze a total number of 407 cases of patients who have received surgery treatment for breast cancer. Results There were fifty patients who have developed bone metastases postoperatively. There were fifty- five percent of patients who have developed bone metastases in 30 months; Seventy-six percent of patients developed bone metastases in 5 years; Sixty percent of patients are under the age of 50. In term of pathology, eighty-two percent of patients have developed invasive ductal carcinoma. The most common metastases sites were thoracic vertebra and lumbar vertebra.Then were pelvis, costal bone, sternum. Less common sites were cranial bone and bones of lower limb. In both metastases cases, there were no statistics difference in examining factors of ages, axillary lymph node metastases, PR and oncogene CerbB2 expressions （P〉0.05）. There were statistical significance between bone metastases of breast cancer and pathology types and ER （P〈0.05）. Conclusions It is common for breast cancer patients to develop bone metastases within 30 months after surgery. The common metastases sites are vertebral column, pelvis, costal bone and sternum. Postoperative bone metastases and internal organs metastasis complications express no relationship with age, axillary lymph node metastases, PRand CerbB2 expressions. Bone metastases of breast cancer is related to pathology types and ER.