男性和女性类风湿关节炎临床特点对比研究

目的 对比男性和女性类风湿关节炎(RA)的临床特点,分析二者的差异,指导临床决策.方法 采用回顾性分析方法,对95例男性和248例女性RA患者的临床特点进行对比研究.结果 男性RA患者发病年龄为18～79(51.40±15.55)岁,明显晚于女性RA患者的18～75(43.54±15.46)岁(P=0.0002);男性RA患者晨僵时间[(1.58±1.34)h]明显短于女性RA患者[(2.10±1.51)h](P=0.0357);男性与女性RA患者首发受累关节发生率比较差异有统计学意义(P=0.0170),且膝、跖趾、肩及踝等负重关节男性发生率明显高于女性,而腕关节发生率女性高于男性.男性RA患者继发性干燥综合征发生率13.68%(13/95),明显低于女性RA患者的35.08%(87/248),差异有统计学意义(P=0.0007).男性RA患者抗核抗体(ANA)阳性率[2.11%(2/95)]和IgM值[(1.42±0.75)g/L]较女性RA患者[10.48%(26/248)和(1.69±0.86)g/L]偏低,差异有统计学意义(P<0.05).男性与女性RA患者其他关节X线表现、关节外表现及实验室检查指标比较差异无统计学意义(P>0.05).结论 男性RA患者发病年龄晚,关节症状较女性轻.男性RA更易受累负重关节.男性与女性RA的严重程度基本相似.女性RA患者更易继发干燥综合征.

Abstract：

Objective To compare and analyze the different clinical features between male and female patients with rheumatoid arthritis (RA), by detecting the gender difference to make clinical decisions. Method The clinical features of 95 male RA patients(MRA) were analyzed and compared with those of 248 female RA patients (FRA) by retrospective analysis method. Results The mean onset age of MRA [18-79 (51.40±15.55) years old] was older than that of FRA[18-75(43.54 ±15.46) years old](P=0.0002). The morning stiffness time of MRA [(1.58 ±1.34) h] was shorter than that of FRA [(2.10 ±1.51) h](P = 0.0357). There was statistical difference in the first involved joint between MRA and FRA (P=0.0170), the prevalence of knee,metatarsonphalangeal joint,shoulder and ankle of MRA was higher than those of FRA, ' but conversely the wrist prevalence of FRA was higher than that of MRA.The prevalence of secondary Sj(o)gren syndrome of MRA(13.68%, 13/95) was rather lower than that of FRA(35.08%, 87/248)(P = 0.0007). MRA had lower positive rate of ANA (2.11% ,2/95) and lower value of IgM [(1.42 ±0.75) g/L] than FRA [(10.48% ,26/248), (1.69 ±0.86) g/L] (P < 0.05). There was no statistical difference between MRA and FRA in articular radiographic changes, most extraarticular manifestations and lab results (P >0.05). Conclusions MRA patients have older onset age and milder articular symptom than FRA patients. The disease severity of MRA is similar to that of FRA. Weighted joints are more involved in MRA. FRA is more inclined to have secondary Sj(o)gren syndrome.

Comparative study on clinical features of male and female patients with rheumatoid arthritis

Objective To compare and analyze the different clinical features between male and female patients with rheumatoid arthritis (RA), by detecting the gender difference to make clinical decisions. Method The clinical features of 95 male RA patients(MRA) were analyzed and compared with those of 248 female RA patients (FRA) by retrospective analysis method. Results The mean onset age of MRA [18-79 (51.40±15.55) years old] was older than that of FRA[18-75(43.54 ±15.46) years old](P=0.0002). The morning stiffness time of MRA [(1.58 ±1.34) h] was shorter than that of FRA [(2.10 ±1.51) h](P = 0.0357). There was statistical difference in the first involved joint between MRA and FRA (P=0.0170), the prevalence of knee,metatarsonphalangeal joint,shoulder and ankle of MRA was higher than those of FRA, ' but conversely the wrist prevalence of FRA was higher than that of MRA.The prevalence of secondary Sj(o)gren syndrome of MRA(13.68%, 13/95) was rather lower than that of FRA(35.08%, 87/248)(P = 0.0007). MRA had lower positive rate of ANA (2.11% ,2/95) and lower value of IgM [(1.42 ±0.75) g/L] than FRA [(10.48% ,26/248), (1.69 ±0.86) g/L] (P < 0.05). There was no statistical difference between MRA and FRA in articular radiographic changes, most extraarticular manifestations and lab results (P >0.05). Conclusions MRA patients have older onset age and milder articular symptom than FRA patients. The disease severity of MRA is similar to that of FRA. Weighted joints are more involved in MRA. FRA is more inclined to have secondary Sj(o)gren syndrome.