A new synthesis analysis method for building logistic regression prediction models

Synthesis analysis refers to a statistical method that integrates multiple univariate regression models and the correlation between each pair of predictors into a single multivariate regression model. The practical application of such a method could be developing a multivariate disease prediction model where a dataset containing the disease outcome and every predictor of interest is not available. In this study, we propose a new version of synthesis analysis that is specific to binary outcomes. We show that our proposed method possesses desirable statistical properties. We also conduct a simulation study to assess the robustness of the proposed method and compare it to a competing method. Copyright © 2014 John Wiley & Sons, Ltd.